Evidence map›Paper›PMID 36790148›Full record

ArticleJournal of feline medicine and surgery2023

Does preappointment gabapentin affect neurological examination findings? A prospective, randomized and blinded study in healthy cats.

André F de Azevedo, Tayná M Veronezi, Izadora L Zardo, João Vb Ferronatto, Kirian R Franck, Adriana G Spiering, Luciana N Nunes, Fernanda Va da Costa

Open access · diamondAbstract readRandomized Controlled Trial, Veterinary
In one paragraph

Article in Journal of feline medicine and surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

André F de AzevedoPost Graduation Program in Veterinary Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Tayná M VeroneziPost Graduation Program in Veterinary Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Izadora L ZardoPost Graduation Program in Veterinary Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
João Vb FerronattoPost Graduation Program in Veterinary Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Kirian R FranckPost Graduation Program in Veterinary Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Adriana G SpieringGraduation Program in Veterinary Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Luciana N NunesDepartment of Statistics, Institute of Mathematics, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Fernanda Va da CostaDepartment of Animal Medicine, Veterinary Faculty, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.ORCID 0000-0002-1031-7728
Universidade Federal do Rio Grande do Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of this study was to evaluate the influence of a preappointment oral dose of gabapentin on the neurological examination of cats.

methodsA prospective, randomized and blinded clinical trial was conducted in 35 client-owned healthy cats. Cats were scheduled for two appointments and randomly assigned to receive either a placebo or a 100 mg gabapentin capsule prior to the second veterinary visit. A neurological examination was performed during each visit, and the results were compared between groups. Normal/abnormal response rates for each test were based on the number of cats that allowed the test to be performed.

resultsGabapentin was administered to 17 cats. Gait and postural reactions were significantly affected in the gabapentin group. Comparing the gabapentin with the placebo groups, proprioceptive ataxia was identified in 4/17 (23.5%) vs 0/18 cats ( CONCLUSIONS AND RELEVANCE: Gabapentin significantly altered gait analyses and postural reactions in this group of healthy cats. The administration of gabapentin could lead to false-positive results and, possibly, an incorrect identification of neurological lesions. In contrast, gabapentin did not impair the assessment of cranial nerves and spinal reflexes, which can be assessed in patients receiving the drug.

Indexed as

Gait AnalysisResearch DesignAnimalsCatsDouble-Blind MethodGabapentinNeurologic ExaminationProspective StudiesGabapentinanxiolyticataxiaCat-friendly practicecutaneous truncigaitneurological exampostural reactionsproprioceptionsedation

Identifiers

PMID36790148
PMCPMC10812070
OpenAlexW4320856159

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.