Evidence map›Paper›PMID 36790143›Full record

ArticleeLife2023

Structural insights into actin isoforms.

Amandeep S Arora, Hsiang-Ling Huang, Ramanpreet Singh, Yoshie Narui, Andrejus Suchenko, Tomoyuki Hatano, Sarah M Heissler, Mohan K Balasubramanian, Krishna Chinthalapudi

Abstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Actin cytoskeletal dynamics in hepatic myofibroblasts and fibrosis.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. The Baraitser-Winter Cerebrofrontofacial Syndrome Recurrent R196H Variant in Cytoplasmic β-Actin Impairs Its Cellular Polymerization and Stability.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  6. Article
  7. Macrophage Actin Cytoskeleton in Chronic Rejection.Results and problems in cell differentiation · 2026
    Review
  8. Article
  9. Article
  10. Article
  11. Eppur si muove: the dynamic brain pericyte.Fluids and barriers of the CNS · 2025
    Review
  12. Article
  13. Study of Cytotoxicity of 3-Azabicyclo[3.1.0]hexanes and Cyclopropa[International journal of molecular sciences · 2025
    Article
  14. Article
  15. Review
  16. Article
  17. Screening and identification of protein 29 ofFrontiers in cellular and infection microbiology · 2025
    Article
  18. Article
  19. Article
  20. Extreme Phenotypic Variability ofAdvanced genetics (Hoboken, N.J.) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Amandeep S AroraDepartment of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, Columbus, United States.ORCID 0000-0003-1045-1967
Hsiang-Ling HuangDepartment of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, Columbus, United States.
Ramanpreet SinghDepartment of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, Columbus, United States.
Yoshie NaruiCenter for Electron Microscopy and Analysis, The Ohio State University, Columbus, United States.
Andrejus SuchenkoCentre for Mechanochemical Cell Biology and Warwick Medical School, Division of Biomedical Sciences, Coventry, United Kingdom.
Tomoyuki HatanoCentre for Mechanochemical Cell Biology and Warwick Medical School, Division of Biomedical Sciences, Coventry, United Kingdom.ORCID 0000-0002-9092-3989
Sarah M HeisslerDepartment of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, Columbus, United States.
Mohan K BalasubramanianCentre for Mechanochemical Cell Biology and Warwick Medical School, Division of Biomedical Sciences, Coventry, United Kingdom.ORCID 0000-0002-1292-8602
Krishna ChinthalapudiDepartment of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, Columbus, United States.ORCID 0000-0003-3669-561X

Funding

Structure and function of nonmuscle myosinsR01GM143539 · NIGMS · OHIO STATE UNIVERSITY · PI CHINTHALAPUDI, KRISHNA · 2021 to 2025
$2.1M
Molecular Mechanisms of Myosin-3R01GM143414 · NIGMS · OHIO STATE UNIVERSITY · PI HEISSLER, SARAH · 2021 to 2025
$1.7M
Consequences of myosin-1G dimerization on its regulated interaction with actinK22HL131869 · NHLBI · OHIO STATE UNIVERSITY · PI HEISSLER, SARAH · 2018 to 2020
$727k
Biotechnology and Biological Sciences Research Council BB/S003789/1Biotechnology and Biological Sciences Research Council BB/X512023/1NHLBI NIH HHS K22 HL131869NIGMS NIH HHS R01 GM143414NIGMS NIH HHS R01 GM143539NIH HHS K22HL131869NIH HHS R01GM143414NIH HHS R01GM143539Wellcome TrustWellcome Trust 203276/Z/16/Z
6 · The paper itself

Abstract

Actin isoforms organize into distinct networks that are essential for the normal function of eukaryotic cells. Despite a high level of sequence and structure conservation, subtle differences in their design principles determine the interaction with myosin motors and actin-binding proteins. Therefore, identifying how the structure of actin isoforms relates to function is important for our understanding of normal cytoskeletal physiology. Here, we report the high-resolution structures of filamentous skeletal muscle α-actin (3.37 Å), cardiac muscle α-actin (3.07 Å), ß-actin (2.99 Å), and γ-actin (3.38 Å) in the Mg

Indexed as

ActinsMyosinsActin CytoskeletonMuscle, SkeletalProtein IsoformsActinsMyosinsProtein Isoformsactinbiochemistrychemical biologycytoskeletonisoformsmacromolecular structuremolecular biophysicsmyosinnonestructural biology

Identifiers

PMID36790143
PMCPMC10072879

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.