SynthesisThe American journal of clinical nutrition2023
Prediagnostic serum calcium concentrations and risk of colorectal cancer development in 2 large European prospective cohorts.
Synthesis in The American journal of clinical nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Global, regional, national burden of colorectal cancer from 1990 to 2021, with projections of incidence to 2050: a systematic analysis of the global burden of disease study 2021.Frontiers in oncology · 2025Pooled it
- Obesity, Bariatric Surgery, and Cancer Risk: Nutritional Perspectives and Long-Term Clinical Implications.Nutrients · 2026Review
- Global, regional, and national trends in colorectal cancer from 2010 to 2021: an analysis of the global burden of disease study 2021.Annals of medicine · 2025Article
- Zinc, copper, copper-to-zinc ratio, and other biometals in blood serum and tumor tissue of patients with colorectal cancer.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Article
- Predictive value of serum calcium ion level in patients with colorectal cancer: A retrospective cohort study.World journal of gastrointestinal surgery · 2025Article
- Diet-wide analyses for risk of colorectal cancer: prospective study of 12,251 incident cases among 542,778 women in the UK.Nature communications · 2025Article
- Exploring the Chemopreventive Effect of Medication on Gene Expression Linked to Colorectal Cancer: An Observational and Mendelian Randomization Analysis in Healthy Colon Mucosa.International journal of molecular sciences · 2024Observational
- Review
- Identification of phenomic data in the pathogenesis of cancers of the gastrointestinal (GI) tract in the UK biobank.Scientific reports · 2024Article
- Are Twin Pregnancies at Higher Risk for Iron and Calcium Deficiency than Singleton Pregnancies?Nutrients · 2023Article
- Determination of Calcium in Meat Products by Automatic Titration with 1,2-Diaminocyclohexane-N,N,N',N'-tetraacetic Acid.Molecules (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
42 authors at 20 institutions in 13 countries.
Funding
Abstract
backgroundHigher dietary calcium consumption is associated with lower colorectal cancer (CRC) risk. However, little data are available on the association between circulating calcium concentrations and CRC risk.
objectivesTo explore the association between circulating calcium concentrations and CRC risk using data from 2 large European prospective cohort studies.
methodsConditional logistic regression models were used to calculate multivariable-adjusted ORs and 95% CIs in case-control studies nested within the European Prospective Investigation into Cancer and Nutrition (EPIC; n-cases = 947, n-controls = 947) and the UK Biobank (UK-BB; n-cases = 2759, n-controls = 12,021) cohorts.
resultsIn EPIC, nonalbumin-adjusted total serum calcium (a proxy of free calcium) was not associated with CRC (OR: 0.94; 95% CI: 0.85, 1.03; modeled as continuous variable, per 1 mg/dL increase), colon cancer (OR: 0.93; 95% CI: 0.82, 1.05) or rectal cancer (OR: 1.01; 95% CI: 0.84, 1.20) risk in the multivariable adjusted model. In the UK-BB, serum ionized calcium (free calcium, most active form) was inversely associated with the risk of CRC (OR: 0.85; 95% CI: 0.76, 0.95; per 1 mg/dL) and colon cancer (OR: 0.78; 95% CI: 0.68, 0.90), but not rectal cancer (OR: 1.02; 95% CI: 0.83, 1.24) in multivariable adjusted models. Meta-analysis of EPIC and UK-BB CRC risk estimates showed an inverse risk association for CRC in the multivariable adjusted model (OR: 0.90; 95%CI: 0.84, 0.97). In analyses by quintiles, in both cohorts, higher levels of serum calcium were associated with reduced CRC risk (EPIC: OR
conclusionsIn UK-BB, higher serum ionized calcium levels were inversely associated with CRC, but the risk was restricted to the colon. Total serum calcium showed a null association in EPIC. Additional prospective studies in other populations are needed to better investigate these associations.
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