ArticleThe American journal of clinical nutrition2023
Dietary phytoestrogens and total and cause-specific mortality: results from 2 prospective cohort studies.
Article in The American journal of clinical nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Impact of Plant-Based Drinks on Cardiometabolic Outcomes: A Systematic Review and Network Meta-analysis.Advances in nutrition (Bethesda, Md.) · 2026Pooled it
- Associations of soy product intake with all-cause, cardiovascular disease and cancer mortality: Guangzhou Biobank Cohort Study and updated meta-analyses.European journal of nutrition · 2024Pooled it
- Impact of one-year soy protein supplementation on serum metabolomic profiles: results from a randomized, placebo-controlled trial in prostate cancer patients.Nutrition and food science · 2026Article
- Effect ofJournal of microbiology and biotechnology · 2026Article
- Elevated urinary phytoestrogens are associated with delayed biological aging: a cross-sectional analysis of NHANES data.Scientific reports · 2025Article
- Lignan Intake and Mortality Among Adults with Incident Type 2 Diabetes-Prospective Cohort Studies.The American journal of clinical nutrition · 2025Article
- Effect of dietary phenolic compounds intake on mortality in the "Seguimiento Universidad De Navarra" (SUN) Mediterranean cohort.European journal of nutrition · 2025Article
- Associations of urinary enterolignans and risk of overall and cause-specific mortality with or without serum albumin adjustment: a prospective cohort study.Frontiers in nutrition · 2025Article
- Dietary soy and isoflavone intake and mortality in Korean adults: a prospective cohort study.Frontiers in nutrition · 2025Article
- Article
- Sex and Age Differences in the Effects of Food Frequency on Metabolic Parameters in Japanese Adults.Nutrients · 2024Observational
- Lignan Intake and Type 2 Diabetes Incidence Among US Men and Women.JAMA network open · 2024Article
- Beneficial Effects of Dietary Flaxseed Oil through Inflammation Pathways and Gut Microbiota in Streptozotocin-Induced Diabetic Mice.Foods (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundEvidence regarding dietary phytoestrogens in relation to mortality remains limited.
objectivesThe objective of the study is to examine the associations of intake of isoflavones, lignans, and coumarins with total and cause-specific mortality in US males and females.
methodsWe followed 75,981 females in the Nurses' Health Study (1984-2018) and 44,001 males in the Health Professionals Follow-up Study (1986-2018), who were free of cardiovascular disease (CVD), diabetes, or cancer at baseline. Their diet was repeatedly assessed using validated food frequency questionnaires every 2-4 y. Associations with mortality were assessed using time-dependent Cox models with adjustments for demographics, dietary and lifestyle factors, and medical history.
resultsDuring 3,427,156 person-years of follow-up, we documented 50,734 deaths, including 12,492 CVD deaths, 13,726 cancer deaths, and 24,516 other non-CVD and noncancer deaths. After multivariable adjustment, the higher total phytoestrogen intake was associated with lower risk of total CVD and other non-CVD and noncancer mortality: comparing extreme quintiles, the pooled HRs (95% CIs) were 0.89 (0.87, 0.92), 0.90 (0.85, 0.96), and 0.86 (0.82, 0.90), respectively. We did not find a significant association with cancer mortality [0.97 (0.92, 1.03)]. For individual phytoestrogens in relation to total mortality, the pooled HRs (95% CIs) comparing extreme quintiles were 0.90 (0.87, 0.92) for isoflavones, 0.93 (0.90, 0.96) for lignans, and 0.93 (0.90, 0.95) for coumarins. Individual phytoestrogens were also significantly associated with lower risk of CVD mortality and other types of mortality. Primary food sources of phytoestrogens, including tofu, soy milk, whole grains, tea, and flaxseed, were also inversely associated with total mortality.
conclusionsA higher intake of total phytoestrogens, including isoflavones, lignans, and coumarins, and foods rich in these compounds was associated with lower risk of total and certain cause-specific mortality in generally healthy US adults. These data suggest that these phytochemicals and their dietary sources may be integrated into an overall healthy diet to achieve a longer life span.
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