ArticleJournal of the American Heart Association2023
Sleep Irregularity and Subclinical Markers of Cardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis.
Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed.
- Sleep Duration and Mortality in Women: Effect of Aging and Menopause.Sleep medicine clinics · 2026Review
- Artificial intelligence-enhanced wearable technology enables ventricular arrhythmia prediction.European heart journal. Digital health · 2026Article
- Evaluation of an in vivo biomarker of arteriolosclerosis (ARTS) and its associations with cognition and multimodal ATN(V) biomarkers in a cardiometabolic-risk enriched community cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Sleep and Risk for Heart Disease and Stroke.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Cardiovascular risk in narcolepsy: Comparison of type 1 and type 2 in a real-world cohort.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
- Association of Rest-Activity Rhythm and Sleep Regularity With Cardiometabolic Disease in the CARDIA Study.Journal of the American Heart Association · 2026Article
- Sleep timing irregularity in midlife: association with incident major adverse cardiac events and cardiovascular disease mortality over a 10-year follow-up.BMC cardiovascular disorders · 2026Article
- Longitudinal association between sleep and Alzheimer's pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Fluctuations in Sleep Duration and Timing and Cardiometabolic Risk.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- From wrist data to lifespan: elucidating inflammation-driven biological aging via activity rhythms captured by wearable devices.npj aging · 2026Article
- Associations of accelerometer-estimated sleep with cardiorespiratory fitness and energetic efficiency among middle-aged and older adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Evaluation of an in vivo biomarker of arteriolosclerosis (ARTS) and its associations with cognition and multimodal ATN(V) biomarkers in a cardiometabolic-risk enriched community cohort.medRxiv : the preprint server for health sciences · 2025Article
- Dream Patterns in Patients with Acute Myocardial Infarction: Data from the STEP-IN-AMI Trial.Journal of clinical medicine · 2025Article
- Article
- Digital Biometrics in Predicting Risk for Obstructive Sleep Apnea and Hypertension: Decentralized, Prospective Cohort Study.Journal of medical Internet research · 2025Article
- Associations between gestational polybrominated diphenyl ether (PBDE) serum concentrations and child sleep outcomes from ages 2-8 years.Environmental research · 2025Article
- Inflammation-resolution signalling in cardiac repair, remodelling, and heart failure.European heart journal open · 2025Review
- Methods for Assessment of Sleep and Circadian Rhythms in Cardiovascular Research.Current hypertension reports · 2025Review
- Unravelling telemonitoring data to predict good NIV quality: the E-QualiNIV study.BMJ open respiratory research · 2025Article
- Association of Life's Essential 8 Scores with Carotid Artery Plaque in Chinese Adults: A Prospective Cohort Study.Journal of atherosclerosis and thrombosis · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Background Sleep irregularity has been linked to incident cardiovascular disease. Less is known about associations of sleep regularity with atherosclerosis. We examined cross-sectional associations of actigraphy-assessed sleep duration and sleep timing regularity with subclinical atherosclerosis in the community-based MESA (Multi-Ethnic Study of Atherosclerosis). Methods and Results MESA Sleep Ancillary Study participants (N=2032; mean age, 68.6±9.2 years; 37.9% White) completed 7-day wrist actigraphy. Participants underwent assessments of coronary artery calcium, carotid plaque presence, carotid intima-media thickness, and the ankle-brachial index. Sleep regularity was quantified by the 7-day with-in person SD of sleep duration and sleep onset timing. Relative risk regression models were used to calculate prevalence ratios and 95% CIs. Models are adjusted for demographics, cardiovascular disease risk factors, and other objectively assessed sleep characteristics including obstructive sleep apnea, sleep duration, and sleep fragmentation. After adjustment, compared with participants with more regular sleep durations (SD ≤60 minutes), participants with greater sleep duration irregularity (SD >120 minutes) were more likely to have high coronary artery calcium burden (>300; prevalence ratio, 1.33 [95% CI, 1.03-1.71]) and abnormal ankle-brachial index (<0.9; prevalence ratio, 1.75 [95% CI, 1.03-2.95]). Compared with participants with more regular sleep timing (SD ≤30 minutes), participants with irregular sleep timing (SD >90 minutes) were more likely to have high coronary artery calcium burden (prevalence ratio, 1.39 [95% CI, 1.07-1.82]). Associations persisted after adjustment for cardiovascular disease risk factors and average sleep duration, obstructive sleep apnea, and sleep fragmentation. Conclusions Sleep irregularity, particularly sleep duration irregularity, was associated with several measures of subclinical atherosclerosis. Sleep regularity may be a modifiable target for reducing atherosclerosis risk. Future investigation into cardiovascular risk reduction interventions targeting sleep irregularity may be warranted.
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