Evidence map›Paper›PMID 36789774›Full record

ReviewStroke2023

Precision Medicine in Neurocritical Care for Cerebrovascular Disease Cases.

Nils H Petersen, Kevin N Sheth, Ruchira M Jha

Open access · greenAbstract readReview
In one paragraph

Review in Stroke, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Precision Medicine for Blood Glutamate Grabbing in Ischemic Stroke.International journal of molecular sciences · 2024
    Observational
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Nils H PetersenDepartments of Neurology (N.H.P., K.N.S., R.M.J.), Yale University School of Medicine, New Haven, CT.ORCID 0000-0001-9711-3340
Kevin N ShethDepartments of Neurology (N.H.P., K.N.S., R.M.J.), Yale University School of Medicine, New Haven, CT.ORCID 0000-0003-2003-5473
Ruchira M JhaDepartments of Neurology (N.H.P., K.N.S., R.M.J.), Yale University School of Medicine, New Haven, CT.ORCID 0000-0002-3047-7649
Barrow Neurological Institute · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
A Translational Evaluation of Sur1-Trpm4 Imaging Endophenotypes and Genetics to Direct Precision Medicine for Cerebral Edema After Traumatic Brain InjuryR01NS115815 · NINDS · ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER · PI JHA, RUCHIRA MENKA · 2021 to 2025
$2.8M
Precision blood pressure management after endovascular stroke therapy based on real-time autoregulation measurementsK23NS110980 · NINDS · YALE UNIVERSITY · PI PETERSEN, NILS H. · 2020 to 2024
$951k
Translational assessment of sulfonylurea receptor-1 as a biomarker and therapeutic target for cerebral edema in traumatic brain injuryK23NS101036 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JHA, RUCHIRA MENKA · 2017 to 2021
$944k
NCATS NIH HHS UL1 TR001863NINDS NIH HHS K23 NS101036NINDS NIH HHS K23 NS110980NINDS NIH HHS R01 NS115815
6 · The paper itself

Abstract

Scientific advances have informed many aspects of acute stroke care but have also highlighted the complexity and heterogeneity of cerebrovascular diseases. While practice guidelines are essential in supporting the clinical decision-making process, they may not capture the nuances of individual cases. Personalized stroke care in ICU has traditionally relied on integrating clinical examinations, neuroimaging studies, and physiologic monitoring to develop a treatment plan tailored to the individual patient. However, to realize the potential of precision medicine in stroke, we need advances and evidence in several critical areas, including data capture, clinical phenotyping, serum biomarker development, neuromonitoring, and physiology-based treatment targets. Mathematical tools are being developed to analyze the multitude of data and provide clinicians with real-time information and personalized treatment targets for the critical care management of patients with cerebrovascular diseases. This review summarizes research advances in these areas and outlines principles for translating precision medicine into clinical practice.

Indexed as

Precision MedicineStrokeCritical CareHumansMonitoring, Physiologiccerebrovascular diseasecritical caredecision-makingprecision medicinestroke

Identifiers

PMID36789774
PMCPMC10348371
OpenAlexW4320856412

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.