ArticleGut and liver2023
Comparison of Interleukin-6, C-Reactive Protein, Procalcitonin, and the Computed Tomography Severity Index for Early Prediction of Severity of Acute Pancreatitis.
Article in Gut and liver, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Evaluating the risk of elevated IL-6 levels in pediatric patients: a stratified approach and evidence of interaction effects.Translational pediatrics · 2026Article
- Development and external validation of a machine learning model for predicting chronic critical illness in ICU patients with acute pancreatitis.BMC medical informatics and decision making · 2026Article
- Spexin as a Novel Biomarker for Predicting Disease Severity and Mortality in Acute Pancreatitis.International journal of molecular sciences · 2026Article
- Inflammation, Organ Failure, and the Path to Surgery in Acute Pancreatitis.Medicina (Kaunas, Lithuania) · 2026Article
- A Practical Guide to the Roles of Procalcitonin Measurement in Patients with Acute Pancreatitis.Journal of clinical medicine · 2026Review
- The association between inflammatory indices and acute pancreatitis severity: a retrospective cohort study.Frontiers in surgery · 2026Article
- Lactate Dehydrogenase, Interleukin-6, and 24 h Intra-Abdominal Pressure Exhibit Early Predictive Value in Hypertriglyceridemic Pancreatitis Complicated by Acute Respiratory Distress Syndrome.Emergency medicine international · 2026Article
- Multisystem laboratory changes before and after blood purification in acute pancreatitis: a real-world descriptive analysis of 141 cases.Frontiers in medicine · 2026Article
- A recurrence prediction model based on serological indicators in children with acute pancreatitis without pancreaticobiliary anatomical abnormalities.Frontiers in pediatrics · 2026Article
- Serum REG1A protein is a biomarker for diagnosis and progression prediction of pancreatitis.BMC gastroenterology · 2025Article
- Article
- Comprehensive statistical analysis of serum interleukin-6 and C-reactive protein for early diagnosis of severe acute pancreatitis: A systematic review and meta-analysis.Journal of family medicine and primary care · 2025Article
- Endoscopic management of infected necrotizing pancreatitis: Advancing through standardization.World journal of gastroenterology · 2025Review
- Diagnostic accuracy of interleukin-6 as a biomarker for early prediction of severe acute pancreatitis: A systematic review and meta-analysis.Journal of family medicine and primary care · 2025Article
- Clinical significance of PCT, CRP, IL-6, NLR, and TyG Index in early diagnosis and severity assessment of acute pancreatitis: A retrospective analysis.Scientific reports · 2025Article
- Effect and safety of sivelestat on acute severe pancreatitis with systemic inflammatory response syndrome: a retrospective study.Scientific reports · 2025Article
- Role of Interleukin 6 in Acute Pancreatitis: A Possible Marker for Disease Prognosis.International journal of molecular sciences · 2024Review
- Serum Lactate Is an Indicator for Short-Term and Long-Term Mortality in Patients with Acute Pancreatitis.Digestive diseases and sciences · 2024Article
- Circulating Biomarkers Involved in the Development of and Progression to Chronic Pancreatitis-A Literature Review.Biomolecules · 2024Review
- The relationship between inflammatory cytokines and in-hospital complications of acute pancreatitis.Immunity, inflammation and disease · 2024Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/Aims: Acute pancreatitis (AP) is a common gastrointestinal disease associated with hospitalization. With the increase in its incidence, AP has become a greater burden on healthcare resources. Early identification of patients with mild AP can facilitate the appropriate use of resources. We aimed to investigate the ability of inflammatory markers, including interleukin-6 (IL-6), procalcitonin, and C-reactive protein (CRP), as well as various scoring systems to differentiate mild AP from more severe diseases. Methods: We retrospectively investigated patients hospitalized with AP, for whom severity assessment and clinical course confirmation were possible. Inflammatory markers were measured at admission, and CRP levels were measured 24 hours after admission (CRP2). Predictive values were calculated using the area under the receiver operating characteristic curve (AUROC) and logistic regression model analysis. Results: Of 103 patients with AP, 42 (40.8%) were diagnosed with mild AP according to the revised Atlanta classification. Based on the AUROC, IL-6 (0.755, p<0.001), CRP2 (0.787, p<0.001), and computed tomography severity index (CTSI) (0.851, p<0.001) were useful predictors of mild AP. With standard cutoff values, the diagnostic sensitivity, specificity, and accuracy were 83.3%, 62.3%, and 70.9% for IL-6 (<50 pg/mL), and 78.6%, 63.9%, and 69.9% for CRP2 (<50 mg/L), respectively. The AUROC of IL-6 and CRP2 were significantly higher than those of other inflammatory markers and were not significantly different from that of CTSI. Conclusions: IL-6, CRP2, and CTSI are helpful for early differentiation of AP severity. Among inflammatory markers, IL-6 has the advantage of early prediction of mild pancreatitis at the time of admission.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.