ArticleThe journals of gerontology. Series B, Psychological sciences and social sciences2023
Associations Between Loneliness and Cognitive Resilience to Neuropathology in Older Adults.
Article in The journals of gerontology. Series B, Psychological sciences and social sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Loneliness Subtypes and Their Association With Prevalent and Incident Dementia.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2026Article
- Trajectories and influencing factors of social alienation in first-onset stroke patients: a prospective cohort study.BMC public health · 2025Article
- Loneliness and Biomarkers of Alzheimer's Disease, Axonal Damage, and Astrogliosis: A Coordinated Analysis of Two Longitudinal Cohorts.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Resilience applications to social isolation and loneliness in older adults: a scoping review to develop a model and research agenda.Frontiers in public health · 2025Article
- Contributions of loneliness to cognitive impairment and dementia in older adults are independent of other risk factors and Alzheimer's pathology: a narrative review.Frontiers in human neuroscience · 2024Review
- Loneliness trajectories and dementia risk: Insights from the HUNT cohort study.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
9 authors.
Funding
Abstract
objectivesLoneliness in the aging population is associated with decreased cognitive function and increased neuropathology; less is understood about the association of loneliness and cognitive resilience (CR), defined as the discordance between a person's actual and expected cognition given their neuropathology. Here we assess the effect of loneliness and change in loneliness on CR at end of life and across older adulthood.
methodsData were combined from 2 longitudinal studies of older adults. CR proximate to death (CRlast_level) and across time (CRslope) was obtained by independently regressing global cognition and change in cognition onto multiple neuropathology indicators and extracting the resulting residuals. We used a series of simple linear regression models to assess the effect of loneliness level and change on CRlast_level and CRslope.
resultsHigher baseline loneliness was associated with lower CRlast_level (β = -0.11, 95% confidence interval [95% CI; -0.18, -0.04], p < .01); higher baseline loneliness and increasing loneliness over time was associated with lower CRslope (β = -0.13, 95% CI [-0.22, -0.05], p < .01 and β = -0.12, 95% CI [-0.20, -0.04], p < .01, respectively). Results were robust to covariate inclusion and independent of objective social isolation. DISCUSSION: Higher and increasing loneliness was associated with lower CR in the face of neuropathology. These results suggest that some individuals are less resilient to the accumulation of neuropathology than others, and experiencing high/increasing loneliness is a key factor putting some at risk. Interventions aimed at optimizing cognitive function across older adults should include loneliness reduction as a potential area of focus.
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