Evidence map›Paper›PMID 36789434›Full record

ArticlebioRxiv : the preprint server for biology2023

A fluid biomarker reveals loss of TDP-43 splicing repression in pre-symptomatic ALS.

Katherine E Irwin, Pei Jasin, Kerstin E Braunstein, Irika Sinha, Kyra D Bowden, Abhay Moghekar, Esther S Oh, Denitza Raitcheva, Dan Bartlett, James D Berry and 3 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 39 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Katherine E IrwinDepartment of Pathology, Johns Hopkins Medicine, Baltimore, MD 21205-2196, USA.
Pei JasinDepartment of Pathology, Johns Hopkins Medicine, Baltimore, MD 21205-2196, USA.
Kerstin E BraunsteinDepartment of Pathology, Johns Hopkins Medicine, Baltimore, MD 21205-2196, USA.
Irika SinhaDepartment of Pathology, Johns Hopkins Medicine, Baltimore, MD 21205-2196, USA.
Kyra D BowdenDepartment of Pathology, Johns Hopkins Medicine, Baltimore, MD 21205-2196, USA.
Abhay MoghekarDepartment of Neurology, Johns Hopkins Medicine, Baltimore, MD 21205-2196, USA.
Esther S OhDepartment of Pathology, Johns Hopkins Medicine, Baltimore, MD 21205-2196, USA.
Denitza RaitchevaBiogen, Cambridge, MA 02142, USA.
Dan BartlettBiogen, Cambridge, MA 02142, USA.
James D BerrySean M Healey & AMG Center for ALS, Massachusetts General Hospital, Boston, MA 02114, USA.
Bryan TraynorNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Jonathan P LingDepartment of Pathology, Johns Hopkins Medicine, Baltimore, MD 21205-2196, USA.
Philip C WongDepartment of Pathology, Johns Hopkins Medicine, Baltimore, MD 21205-2196, USA.
Johns Hopkins University · USBiogen (United States) · USMassachusetts General Hospital · USNational Institutes of Health · US

Funding

TDP-43 Proteinopathy in ALS-FTD: Mechanism, Target Validation and BiomarkerR01NS095969 · NINDS · JOHNS HOPKINS UNIVERSITY · PI PHILIP C WONG · 2016 to 2026
$2.4M
NINDS NIH HHS R01 NS095969
6 · The paper itself

Abstract

Loss of TAR DNA-binding protein 43 kDa (TDP-43) splicing repression is well-documented in postmortem tissues of amyotrophic lateral sclerosis (ALS), yet whether this abnormality occurs during early-stage disease remains unresolved. Cryptic exon inclusion reflects functional loss of TDP-43, and thus detection of cryptic exon-encoded peptides in cerebrospinal fluid (CSF) could reveal the earliest stages of TDP-43 dysregulation in patients. Here, we use a newly characterized monoclonal antibody specific to a TDP-43-dependent cryptic epitope (encoded by the cryptic exon found in

Indexed as

ALScryptic exonCSFpre-symptomaticprognostic biomarkerTDP-43

Identifiers

PMID36789434
PMCPMC9928052
OpenAlexW4317830831

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.