Evidence map›Paper›PMID 36789400›Full record

ArticleHealth science reports2023

Antibody responses to BNT162b2 SARS-CoV-2 mRNA vaccine among healthcare workers and residents of long-term care facilities: A cohort study in Northern Italy.

Costanza Vicentini, Carla Maria Zotti, Alessandro Roberto Cornio, Jacopo Garlasco, Noemi Marengo, Davide Meddis, Savina Ditommaso, Monica Giacomuzzi, Gabriele Memoli, Valerio Bordino and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Health science reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Costanza VicentiniDepartment of Public Health and Paediatrics University of Turin Turin Italy.ORCID 0000-0002-0056-2463
Carla Maria ZottiDepartment of Public Health and Paediatrics University of Turin Turin Italy.
Alessandro Roberto CornioDepartment of Public Health and Paediatrics University of Turin Turin Italy.
Jacopo GarlascoDepartment of Public Health and Paediatrics University of Turin Turin Italy.ORCID 0000-0001-6331-8276
Noemi MarengoDepartment of Public Health and Paediatrics University of Turin Turin Italy.
Davide MeddisDepartment of Public Health and Paediatrics University of Turin Turin Italy.
Savina DitommasoDepartment of Public Health and Paediatrics University of Turin Turin Italy.
Monica GiacomuzziDepartment of Public Health and Paediatrics University of Turin Turin Italy.
Gabriele MemoliDepartment of Public Health and Paediatrics University of Turin Turin Italy.ORCID 0000-0002-7211-079X
Valerio BordinoDepartment of Public Health and Paediatrics University of Turin Turin Italy.ORCID 0000-0002-1173-0469
Maria Michela GianinoDepartment of Public Health and Paediatrics University of Turin Turin Italy.
Collaborating Group
University of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: Long-term care facilities (LTCFs) have been severely impacted by COVID-19, with a disproportionate amount of SARS-CoV-2 infections and related deaths occurring among residents. Methods: This study is part of an ongoing multicenter, prospective cohort study conducted among healthcare workers (HCWs) and residents of 13 LTCFs in Northern Italy designed to evaluate SARS-CoV-2 specific immunoglobulin class G (IgG) titers before and following vaccination with Pfizer/BNT162b2 SARS-CoV-2 mRNA vaccine (two doses of vaccine, 21 days apart). Serum samples were obtained from participants (t0) before vaccination, and (t1) 2 weeks after and analyzed to determine anti-S1 IgG antibodies. Results: Five hundred and thirty-four participants were enrolled (404 subjects participated in both blood draws). Seropositivity was 50.19% at t0 and 99% at t1, with a significant difference in IgG titers. A higher proportion of residents were seropositive at t0 compared with HCWs, with significantly higher IgG titers among residents at both t0 and t1. Pre-existing immunity also had a significant effect on postvaccination IgG titers. However, a significant difference in titers at t1 between HCWs and residents considering only participants seropositive at t0 was found, with higher median titers among previously seropositive residents. Conclusion: Findings of this study provide scientific evidence endorsing the policy of universal vaccination in LTCFs.

Indexed as

immune senescenceItalynursing homesPfizer/BNT162b2SARS‐CoV‐2

Identifiers

PMID36789400
PMCPMC9922049
OpenAlexW4320035945

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.