Evidence map›Paper›PMID 36789176›Full record

ArticleJAC-antimicrobial resistance2023

Sustained increases in antibiotic prescriptions per primary care consultation for upper respiratory tract infections in England during the COVID-19 pandemic.

Zheyuan Yang, Sabine Bou-Antoun, Sarah Gerver, Thomas E Cowling, Rachel Freeman

Abstract read
In one paragraph

Article in JAC-antimicrobial resistance, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  5. Changes in the Appropriateness of US Outpatient Antibiotic Prescribing After the COVID-19 Outbreak: An Interrupted Time Series Analysis of 2016-2021 Data.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zheyuan YangReal World Solutions, IQVIA, 37 North Wharf Road, London W2 1AF, UK.
Sabine Bou-AntounHCAI, Fungal, AMR, AMU and Sepsis Division, UK Health Security Agency, 61 Colindale Avenue, London NW9 5EQ, UK.ORCID https://orcid.org/0000-0002-5640-1490
Sarah GerverHCAI, Fungal, AMR, AMU and Sepsis Division, UK Health Security Agency, 61 Colindale Avenue, London NW9 5EQ, UK.
Thomas E CowlingFaculty of Epidemiology and Population Health, The London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
Rachel FreemanReal World Solutions, IQVIA, 37 North Wharf Road, London W2 1AF, UK.ORCID https://orcid.org/0000-0002-5262-3395

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The responsible use of existing antimicrobials is essential in reducing the threat posed by antimicrobial resistance (AMR). With the introduction of restrictions during the COVID-19 pandemic, a substantial reduction in face-to-face appointments in general practice was observed. To understand if this shift in healthcare provision has impacted on prescribing practices, we investigated antibiotic prescribing for upper respiratory tract infections (URTI) consultations. Methods: We conducted an interrupted time-series analysis using patient-level primary care data to assess the impact of the COVID-19 pandemic on consultations and antibiotic prescribing for URTI in England. Results: We estimated an increase of 105.7 antibiotic items per 1000 URTI consultations (95% CI: 65.6-145.8; Conclusions: Overuse of antibiotics is known to be a driver of resistance and it is essential that efforts to reduce inappropriate prescribing continue subsequent to the COVID-19 pandemic. Further work should examine drivers of increased antibiotic prescribing for URTI to inform the development of targeted antibiotic stewardship interventions.

Identifiers

PMID36789176
PMCPMC9921722

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.