Evidence map›Paper›PMID 36788793›Full record

ArticleiScience2023

SARS-CoV-2 leverages airway epithelial protective mechanism for viral infection.

Allison Marie Greaney, Micha Sam Brickman Raredon, Maria P Kochugaeva, Laura E Niklason, Andre Levchenko

Open access · goldAbstract read
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. COVID-19 Biogenesis and Intracellular Transport.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Allison Marie GreaneyDepartment of Biomedical Engineering, Yale University, New Haven, CT 06511, USA.
Micha Sam Brickman RaredonDepartment of Biomedical Engineering, Yale University, New Haven, CT 06511, USA.
Maria P KochugaevaDepartment of Biomedical Engineering, Yale University, New Haven, CT 06511, USA.
Laura E NiklasonDepartment of Biomedical Engineering, Yale University, New Haven, CT 06511, USA.
Andre LevchenkoDepartment of Biomedical Engineering, Yale University, New Haven, CT 06511, USA.
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Medical Scientist Training ProgramT32GM136651 · NIGMS · YALE UNIVERSITY · PI BARBARA I KAZMIERCZAK · 2020 to 2026
$16.5M
Systems analysis of phenotypic switch in control of cancer invasionU54CA209992 · NCI · YALE UNIVERSITY · PI LEVCHENKO, ANDRE · 2016 to 2021
$10.1M
Research Training in AnesthesiaT32GM086287 · NIGMS · YALE UNIVERSITY · PI ROBERT SCHONBERGER · 2009 to 2026
$3.7M
The Role of Macrophages in Pulmonary Regeneration using a Bioengineered Whole Lung Tissue ModelF32HL162428 · NHLBI · YALE UNIVERSITY · PI GREANEY, ALLISON MARIE · 2022 to 2024
$213k
Reverse Engineering the Pulmonary MicrovasculatureF30HL143906 · NHLBI · YALE UNIVERSITY · PI RAREDON, MICHA SAM · 2019 to 2021
$104k
NCATS NIH HHS UL1 TR001863NCI NIH HHS U54 CA209992NHLBI NIH HHS F30 HL143906NHLBI NIH HHS F32 HL162428NIGMS NIH HHS T32 GM086287NIGMS NIH HHS T32 GM136651
6 · The paper itself

Abstract

Despite much concerted effort to better understand severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral infection, relatively little is known about the dynamics of early viral entry and infection in the airway. Here we analyzed a single-cell RNA sequencing dataset of early SARS-CoV-2 infection in a humanized

Indexed as

Biological sciencesImmunologyTranscriptomicsVirology

Identifiers

PMID36788793
PMCPMC9912025
OpenAlexW4319968047

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.