Evidence map›Paper›PMID 36788737›Full record

ArticleCancer science2023

Targeting of SIRPα as a potential therapy for Langerhans cell histiocytosis.

Takeshi Okamoto, Yoji Murata, Daiichiro Hasegawa, Makiko Yoshida, Daisuke Tanaka, Takashi Ueda, Daisuke Hazama, Okechi S Oduori, Satomi Komori, Tomoko Takai and 5 more

Open access · goldAbstract read
In one paragraph

Article in Cancer science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Takeshi OkamotoDivision of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan.
Yoji MurataDivision of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan.ORCID https://orcid.org/0000-0002-9576-7030
Daiichiro HasegawaDepartment of Hematology & Oncology, Children's Cancer Center, Hyogo Prefectural Kobe Children's Hospital, Kobe, Japan.
Makiko YoshidaDepartment of Pathology, Hyogo Prefectural Kobe Children's Hospital, Kobe, Japan.
Daisuke TanakaDivision of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan.
Takashi UedaDivision of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan.
Daisuke HazamaDivision of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan.
Okechi S OduoriDivision of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan.
Satomi KomoriDivision of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan.
Tomoko TakaiDivision of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan.
Yasuyuki SaitoDivision of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan.
Takenori KotaniDivision of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan.
Yoshiyuki KosakaDepartment of Hematology & Oncology, Children's Cancer Center, Hyogo Prefectural Kobe Children's Hospital, Kobe, Japan.
Yoshimasa ManiwaDivision of Thoracic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Takashi MatozakiDivision of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan.ORCID https://orcid.org/0000-0002-4393-8416
Kobe University · JPKobe Children's Hospital · JP

Funding

Japan Agency for Medical Research and Development 22ama221304h0001Japan Society for the Promotion of Science 22F22103Japan Society for the Promotion of Science 22K06926
6 · The paper itself

Abstract

Langerhans cell histiocytosis (LCH) is a rare neoplastic disorder characterized by inflammatory lesions arising from the anomalous accumulation of pathogenic CD1a

Indexed as

Histiocytosis, Langerhans-CellAnimalsAntigens, DifferentiationHumansMiceReceptors, ImmunologicSpleenAntigens, DifferentiationReceptors, ImmunologicSIRPA protein, humanantibodyLangerhans cell histiocytosismacrophagephagocytosisSIRPα

Identifiers

PMID36788737
PMCPMC10154843
OpenAlexW4320856692

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.