ArticleCurrent neuropharmacology2024
Childhood Trauma and Self-harm in Youths with Bipolar Disorders.
Article in Current neuropharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Lifetime Mixed Depression and Childhood Trauma in Individuals With Bipolar Disorders.Acta psychiatrica Scandinavica · 2026Article
- Lurasidone for Pediatric Bipolar Disorder: A Systematic Review.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Article
- Type of cycle, temperament and childhood trauma are associated with lithium response in patients with bipolar disorders.International journal of bipolar disorders · 2024Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBipolar disorders (BD) in youth are associated with a high risk of self-harm behaviors. Childhood trauma (CT) is a relevant environmental stressor that is related to both BD diagnosis and self-harm in adulthood. It is not yet established whether CT may impact self-harm risk in youth. Therefore, the aim of this study was to investigate the distribution patterns of CT in youth BD with and without self-harm.
methodsWe assessed 273 participants (aged 13-25 years), 96 youths with BD according to DSM-5 criteria and 177 healthy controls (HC). History of CT was obtained using the Childhood Trauma Questionnaire (CTQ). The association between CT and self-harm was tested using multivariate statistical models.
resultsOver 45% of participants with BD reported lifetime self-harm. The BD Self-harm group reported more emotional abuse, emotional neglect, sexual abuse, and physical abuse than HC. The BD No-Self-harm group reported more emotional abuse than HC. The BD Self-harm group reported more emotional abuse and neglect than the BD No-Self-harm group. The BD Self-harm group also reported separated parents, hospitalizations, smoking, use of antiepileptics, antipsychotics and lithium. Emotional abuse was an independent predictor of self-harm in youths with BD.
conclusionFindings support the importance of assessing CT, in particular emotional abuse, in youth with BD at risk for self-harm.
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