ArticleBMC public health2023
Age-specific effects on adverse pregnancy outcomes vary by maternal characteristics: a population-based retrospective study in Xiamen, China.
Article in BMC public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Maternal age 30-34 years and adverse perinatal outcomes: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Prevalence, Trends, and Associated Factors of Malnutrition Among Under Six-Month-Old Infants in Bangladesh: A Pooled Analysis of DHS Data (2011-2022).Maternal & child nutrition · 2026Article
- Association between family health and fertility intention among women of childbearing age in China: evidence from a large multi-stage cross-sectional survey.Journal of global health · 2026Article
- Advanced Maternal Age and Risk of Large-for-Gestational-Age Infants: Mediating Roles of Prenatal Body Mass Index and Specific Lipid Profiles.International journal of women's health · 2026Article
- Temporal trends in lupus pregnancy over four decades in a referral centre: pregnancy planning and hydroxychloroquine use are associated with improved outcomes.Rheumatology advances in practice · 2026Article
- Comparison of clinical outcomes and predictive model analysis between short-term culture and overnight culture after embryo recovery at cleavage stage.Scientific reports · 2025Article
- The optimal childbearing age and birth spacing in china: a multicenter retrospective cohort study.BMC public health · 2025Article
- Risk Factors for Gestational Diabetes Mellitus in Mainland China: A Systematic Review and Meta-Analysis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Review
- Caesarean section delivery and its associated factors in Ghana: A multilevel analysis.PloS one · 2025Article
- Multilevel determinants of child development in socially vulnerable Brazilian children: a longitudinal study.Frontiers in pediatrics · 2025Article
- Advanced maternal age (AMA) and pregnancy: a feasible but problematic event.Archives of gynecology and obstetrics · 2024Review
- Gestational weight gain and its determinants among pregnant women in Gurage zone, Central Ethiopia: a cohort study.BMC women's health · 2024Article
- Development and validation of a prenatal predictive nomogram for the risk of NICU admission in infants born to Chinese mothers over 35 years of age: a retrospective cohort study.BMC pregnancy and childbirth · 2024Article
- [Analysis of Risk Factors for Recurrent Pregnancy Loss in Patients UndergoingSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024Article
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- Effect of advanced maternal age on ischemic stroke vulnerability in aged rats: Investigating on blood-brain barrier permeability and gene expression.Aging brain · 2024Article
- Clinical characteristics and pathologic complete response (pCR) rate after neoadjuvant chemotherapy in postpartum women with breast cancer.Journal of cancer research and clinical oncology · 2023Article
- The relationship between urinary selenium levels and risk of gestational diabetes mellitus: A nested case-control study.Frontiers in public health · 2023Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdvanced maternal age (AMA; ≥35 years) is considered to be a major risk factor for adverse pregnancy outcomes. Along with the global trend of delayed childbearing, and in particular, the implementation of China's second and third-child policy leading to a dramatic increase of AMA in recent years, the association between maternal age and pregnancy outcomes requires more investigation.
methodsA population-based retrospective study was performed. Data were derived from the Medical Birth Registry of Xiamen from 2011 to 2018. Univariate and multivariate logistic regression was used to evaluate the effects of maternal age on pregnancy outcomes.
resultsA total of 63,137 women categorized into different age groups (< 25 years, 25-29 years, 30-34 years, and ≥ 35 years) were included in this study. Compared with the mothers aged 25-29 years, the univariate regression analysis showed that mothers aged < 25 years had lower risks of gestational diabetes mellitus (GDM) and cesarean. AMA was associated with higher risks of GDM, hypertension, cesarean, preterm birth, low-birth weight (LBW), large-for-gestational-age (LGA), macrosomia, and stillbirth (all P < 0.01). After adjustment for potential confounding factors, increased risks of GDM, hypertension, cesarean, preterm birth, and LBW remained significantly associated with AMA (all P < 0.05), whereas AMA mothers showed a lower risk of macrosomia than their younger counterparts. Additionally, no significant differences were detected in terms of Apgar score < 7.
conclusionAMA was associated with adverse pregnancy outcomes including increased risks of GDM, hypertension, cesarean, preterm birth, and LBW. This study confirmed the relationship between AMA and certain adverse maternal and fetal outcomes and emphasizes the necessity for women to be cautious about the age at which they become pregnant.
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