Evidence map›Paper›PMID 36788497›Full record

ArticleBMC medical research methodology2023

Estimating incidence of type 1 and type 2 diabetes using prevalence data: the SEARCH for Diabetes in Youth study.

Annika Hoyer, Ralph Brinks, Thaddäus Tönnies, Sharon H Saydah, Ralph B D'Agostino, Jasmin Divers, Scott Isom, Dana Dabelea, Jean M Lawrence, Elizabeth J Mayer-Davis and 3 more

Abstract read
In one paragraph

Article in BMC medical research methodology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Annika HoyerMedical School OWL, Biostatistics and Medical Biometry, Bielefeld University, Universitätsstr. 25, Bielefeld, 33615, Germany. annika.hoyer@uni-bielefeld.de.
Ralph BrinksChair for Medical Biometry and Epidemiology, Faculty of Health/School of Medicine, Witten/Herdecke University, Witten, Germany.
Thaddäus TönniesInstitute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at the Heinrich Heine University, Düsseldorf, Germany.
Sharon H SaydahDivision of Viral Diseases, National Center for Infectious Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, USA.
Ralph B D'AgostinoDepartment of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Jasmin DiversDivision of Health Services Research, Department of Foundations of Medicine, New York University Langone School of Medicine, Mineola, NY, USA.
Scott IsomDepartment of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Dana DabeleaLifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, Department of Epidemiology, Colorado School of Public Health, University of Colorado, Denver, CO, USA.
Jean M LawrenceDivision of Diabetes, Endocrinology & Metabolic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Elizabeth J Mayer-DavisDepartments of Nutrition and Medicine, Gillings School of Global Public Health and School of Medicine, University of North Carolina, Chapel Hill, NC, USA.
Catherine PihokerDepartment of Pediatrics, University of Washington, Seattle, WA, USA.
Lawrence DolanDivision of Endocrinology, Department of Pediatrics, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Giuseppina ImperatoreDivision of Diabetes Translation, Centers for Disease Control and Prevention (CDC), National Center for Chronic Disease Prevention and Health Promotion, Atlanta, USA.

Funding

SEARCH for Diabetes in Youth Coordinating CenterU01DP000250 · DP · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BELL, RONNY A · 2005 to 2009
$4.8M
SEARCH For Diabetes in Youth, Phase 3: Cohort Study-Carolina CenterU18DP002708 · DP · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAYER-DAVIS, ELIZABETH J · 2010 to 2014
$3.6M
SEARCH for Diabetes in Youth 2: Colorado CenterU01DP000247 · DP · UNIVERSITY OF COLORADO DENVER · PI DABELEA, DANA · 2005 to 2009
$3.6M
SEARCH for Diabetes in Youth 3: Washington Site, Part BU18DP002710 · DP · SEATTLE CHILDREN'S HOSPITAL · PI PIHOKER, CATHERINE · 2010 to 2014
$3.2M
SEARCH for Diabetes in Youth, Phase 3: Cohort Study - California CenterU18DP002714 · DP · KAISER FOUNDATION RESEARCH INSTITUTE · PI LAWRENCE, JEAN MARIE · 2010 to 2014
$3.1M
SEARCH for Diabetes in Youth 2: California CenterU01DP000246 · DP · KAISER FOUNDATION RESEARCH INSTITUTE · PI LAWRENCE, JEAN MARIE · 2005 to 2009
$2.8M
SEARCH for Diabetes in Youth 2: Washington SiteU01DP000244 · DP · SEATTLE CHILDREN'S HOSPITAL · PI PIHOKER, CATHERINE · 2005 to 2009
$2.7M
SEARCH for Diabetes in Youth Registry Study, Phase 4: Carolina Center (Component A)U18DP006138 · DP · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAYER-DAVIS, ELIZABETH J · 2015 to 2019
$1.9M
Population-based diabetes in youth registry. SEARCH For Diabetes in Youth, Phase 4, California SiteU18DP006133 · DP · KAISER FOUNDATION RESEARCH INSTITUTE · PI REYNOLDS, KRISTI · 2015 to 2019
$1.9M
The SEARCH for Diabetes in Youth Registry StudyU18DP006139 · DP · UNIVERSITY OF COLORADO DENVER · PI DABELEA, DANA · 2015 to 2019
$1.9M
SEARCH for Diabetes in Youth Registry Study, Phase 4: Washington CenterU18DP006136 · DP · SEATTLE CHILDREN'S HOSPITAL · PI PIHOKER, CATHERINE · 2015 to 2019
$1.9M
SEARCH for Diabetes in Youth Registry Study, Phase 4: Ohio CenterU18DP006134 · DP · CINCINNATI CHILDRENS HOSP MED CTR · PI DOLAN, LAWRENCE M · 2015 to 2019
$1.8M
NCCDPHP CDC HHS U01 DP000244NCCDPHP CDC HHS U01 DP000246NCCDPHP CDC HHS U01 DP000247NCCDPHP CDC HHS U01 DP000250NCCDPHP CDC HHS U18 DP002708NCCDPHP CDC HHS U18 DP002710NCCDPHP CDC HHS U18 DP002714NCCDPHP CDC HHS U18 DP006133NCCDPHP CDC HHS U18 DP006134NCCDPHP CDC HHS U18 DP006136NCCDPHP CDC HHS U18 DP006138NCCDPHP CDC HHS U18 DP006139
6 · The paper itself

Abstract

backgroundIncidence is one of the most important epidemiologic indices in surveillance. However, determining incidence is complex and requires time-consuming cohort studies or registries with date of diagnosis. Estimating incidence from prevalence using mathematical relationships may facilitate surveillance efforts. The aim of this study was to examine whether a partial differential equation (PDE) can be used to estimate diabetes incidence from prevalence in youth.

methodsWe used age-, sex-, and race/ethnicity-specific estimates of prevalence in 2001 and 2009 as reported in the SEARCH for Diabetes in Youth study. Using these data, a PDE was applied to estimate the average incidence rates of type 1 and type 2 diabetes for the period between 2001 and 2009. Estimates were compared to annual incidence rates observed in SEARCH. Precision of the estimates was evaluated using 95% bootstrap confidence intervals.

resultsDespite the long period between prevalence measures, the estimated average incidence rates mirror the average of the observed annual incidence rates. Absolute values of the age-standardized sex- and type-specific mean relative errors are below 8%.

conclusionsIncidence of diabetes can be accurately estimated from prevalence. Since only cross-sectional prevalence data is required, employing this methodology in future studies may result in considerable cost savings.

Indexed as

Diabetes Mellitus, Type 2AdolescentCohort StudiesCross-Sectional StudiesHumansIncidencePrevalenceAdolescentsChildrenEpidemiologyIllness-death-modelSurveillanceType 1 diabetesType 2 diabetes

Identifiers

PMID36788497
PMCPMC9930314

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.