ArticleInternational journal of obesity (2005)2023
Increased BMI and late-life mobility dysfunction; overlap of genetic effects in brain regions.
Article in International journal of obesity (2005), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 citations in OpenAlex.
- Predictive capabilities of polygenic scores in an East-Asian population-based cohort: the Singapore Chinese health study.Communications biology · 2025Article
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10 authors at 3 institutions in 3 countries.
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Abstract
backgroundHow obesity earlier in life impacts upon mobility dysfunctions in late life is not well understood. Pernicious effects of excess weight on the musculoskeletal system and mobility dysfunctions are well-recognized. However, increasingly more data support the link of obesity to overall motor defects that are regulated in the brain.
objectivesTo assess the causal relationship between body mass index (BMI) at midlife and performance of the Timed Up-and-Go test (TUG) in late life among a population-based longitudinal cohort of Chinese adults living in Singapore.
methodsWe evaluated genetic predispositions for BMI in 8342 participants who were followed up from measurement of BMI at average 53 years, to TUG test (as a functional mobility measure) 20 years later.
resultsA robust 75.83% of genetically determined BMI effects on late-life TUG scores were mediated through midlife BMI (P
conclusionsWe report a causal effect of obesity on mobility dysfunction. Our findings highlight potential neuronal dysfunctions in regulating predispositions on the causal pathway from obesity to mobility dysfunction.
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