Evidence map›Paper›PMID 36788297›Full record

SynthesisMovement disorders : official journal of the Movement Disorder Society2023

Investigation of Shared Genetic Risk Factors Between Parkinson's Disease and Cancers.

Pierre-Emmanuel Sugier, Elise A Lucotte, Cloé Domenighetti, Matthew H Law, Mark M Iles, Kevin Brown, Christopher Amos, James D McKay, Rayjean J Hung, Mojgan Karimi and 86 more

Open access · hybridAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Movement disorders : official journal of the Movement Disorder Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
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  3. Review
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  5. Article
  6. Review
  7. Comprehensive bioinformatics analysis of co-mutation ofTranslational cancer research · 2025
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  9. Brain communications · 2025
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  10. Article
  11. Update: Protective and risk factors for Parkinson disease.Parkinsonism & related disorders · 2024
    Review
  12. Review
  13. Epidemiology of Parkinson's Disease: An Update.Current neurology and neuroscience reports · 2024
    Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

96 authors at 20 institutions in 20 countries.

Pierre-Emmanuel SugierUniversité Paris-Saclay, UVSQ, Inserm, Gustave Roussy, Team "Exposome, Heredity, Cancer and Health", CESP, Villejuif, France.ORCID 0000-0002-5846-1104
Elise A LucotteUniversité Paris-Saclay, UVSQ, Inserm, Gustave Roussy, Team "Exposome, Heredity, Cancer and Health", CESP, Villejuif, France.
Cloé DomenighettiUniversité Paris-Saclay, UVSQ, Inserm, Gustave Roussy, Team "Exposome, Heredity, Cancer and Health", CESP, Villejuif, France.ORCID 0000-0001-6408-0351
Matthew H LawStatistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Mark M IlesSection of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom.
Kevin BrownLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Christopher AmosInstitute for Clinical and Translational Research, Baylor Medical College of Medecine, Houston, Texas, USA.
James D McKayInternational Agency for Research on Cancer, Lyon, France.
Rayjean J HungLunenfeld-Tanenbuaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
Mojgan KarimiUniversité Paris-Saclay, UVSQ, Inserm, Gustave Roussy, Team "Exposome, Heredity, Cancer and Health", CESP, Villejuif, France.
Delphine Bacq-DaianUniversité Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, Evry, France.
Anne Boland-AugéUniversité Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, Evry, France.
Robert OlasoUniversité Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, Evry, France.
Jean-François DeleuzeUniversité Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, Evry, France.
Fabienne LesueurInserm, U900, Institut Curie, PSL University, Mines ParisTech, Paris, France.
Evgenia OstroumovaInternational Agency for Research on Cancer, Lyon, France.
Ausrele KesminieneInternational Agency for Research on Cancer, Lyon, France.
Florent de VathaireUniversité Paris-Saclay, UVSQ, Gustave Roussy, Inserm, Team "Epidemiology of radiations," CESP, Villejuif, France.
Pascal GuénelUniversité Paris-Saclay, UVSQ, Inserm, Gustave Roussy, Team "Exposome, Heredity, Cancer and Health", CESP, Villejuif, France.
EPITHYR consortium
Ashwin Ashok Kumar SreelathaCentre for Genetic Epidemiology, Institute for Clinical Epidemiology and Applied Biometry, University of Tubingen, Tübingen, Germany.
Claudia SchulteDepartment for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, Tübingen, Germany.ORCID 0000-0003-4006-1265
Sandeep GroverCentre for Genetic Epidemiology, Institute for Clinical Epidemiology and Applied Biometry, University of Tubingen, Tübingen, Germany.ORCID 0000-0003-2615-4916
Patrick MayTranslational Neuroscience, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-Belval, Luxembourg.ORCID 0000-0001-8698-3770
Dheeraj R BobbiliTranslational Neuroscience, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-Belval, Luxembourg.ORCID 0000-0002-1368-9623
Milena Radivojkov-BlagojevicInstitute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany.
Peter LichtnerInstitute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany.
Andrew B SingletonMolecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.
Dena G HernandezMolecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.
Connor EdsallMolecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.
George D MellickGriffith Institute for Drug Discovery, Griffith University, Nathan, Australia.
Alexander ZimprichDepartment of Neurology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-1668-5177
Walter PirkerDepartment of Neurology, Klinik Ottakring, Vienna, Austria.
Ekaterina RogaevaTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.
Anthony E LangEdmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Toronto, Ontario, Canada.ORCID 0000-0003-1229-3667
Sulev KoksCentre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Murdoch, Australia.
Pille TabaDepartment of Neurology and Neurosurgery, University of Tartu, Tartu, Estonia.
Suzanne LesageDepartment of Neurology, Sorbonne Université, Institut du Cerveau-Paris Brain Institute-ICM, INSERM, CNRS, Assistance Publique Hôpitaux de Paris, Paris, France.
Alexis BriceDepartment of Neurology, Sorbonne Université, Institut du Cerveau-Paris Brain Institute-ICM, INSERM, CNRS, Assistance Publique Hôpitaux de Paris, Paris, France.
Jean-Christophe CorvolDepartment of Neurology, Sorbonne Université, Institut du Cerveau-Paris Brain Institute-ICM, INSERM, CNRS, Assistance Publique Hôpitaux de Paris, Paris, France.ORCID 0000-0001-7325-0199
Marie-Christine Chartier-HarlinUniversité de Lille, Inserm, CHU Lille, UMR-S 1172, LilNCog, Centre de Recherche Lille Neurosciences & Cognition, Lille, France.
Eugénie MutezUniversité de Lille, Inserm, CHU Lille, UMR-S 1172, LilNCog, Centre de Recherche Lille Neurosciences & Cognition, Lille, France.ORCID 0000-0002-5947-0432
Kathrin BrockmannDepartment for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, Tübingen, Germany.ORCID 0000-0002-7515-8596
Angela B DeutschländerDepartment of Neurology, Ludwig Maximilians University of Munich, Munich, Germany.ORCID 0000-0003-2152-9926
Georges M HadjigeorgiouDepartment of Neurology and Department of Clinical Genomics, Mayo Clinic Florida, Jacksonville, Florida, USA.
Efthimios DardiotisDepartment of Neurology, Laboratory of Neurogenetics, University of Thessaly, University Hospital of Larissa, Larissa, Greece.
Leonidas Stefanis1st Department of Neurology, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.ORCID 0000-0003-3569-8990
Athina Maria Simitsi1st Department of Neurology, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Enza Maria ValenteDepartment of Molecular Medicine, University of Pavia, Pavia, Italy.ORCID 0000-0002-0600-6820
Simona PetrucciUOC Medical Genetics and Advanced Cell Diagnostics, S. Andrea University Hospital, Rome, Italy.
Letizia StranieroDepartment of Biomedical Sciences, Humanitas University, Milan, Italy.
Anna ZecchinelliParkinson Institute, Azienda Socio Sanitaria Territoriale (ASST) Gaetano Pini/CTO, Milan, Italy.
Gianni PezzoliParkinson Institute, Fontazione Grigioni-Via Zuretti, Milan, Italy.
Laura BrighinaDepartment of Neurology, San Gerardo Hospital, Monza, Italy.
Carlo FerrareseDepartment of Neurology, San Gerardo Hospital, Monza, Italy.
Grazia AnnesiInstitute for Biomedical Research and Innovation, National Research Council, Cosenza, Italy.
Andrea QuattroneInstitute of Neurology, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.
Monica GagliardiDepartment of Medical and Surgical Sciences, Neuroscience Research Center, Magna Graecia University, Catanzaro, Italy.
Hirotaka MatsuoDepartment of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Saitama, Japan.
Akiyoshi NakayamaDepartment of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Saitama, Japan.
Nobutaka HattoriDepartment of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Kenya NishiokaDepartment of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Sun Ju ChungDepartment of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.ORCID 0000-0003-4118-8233
Yun Joong KimDepartment of Neurology, Yonsei University College of Medicine, Seoul, South Korea.
Pierre KolberNeurology, Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg.
Bart P C van de WarrenburgDepartment of Neurology, Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands.
Bastiaan R BloemDepartment of Neurology, Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands.
Jan AaslyDepartment of Neurology, St. Olav's Hospital and Norwegian University of Science and Technology, Trondheim, Norway.
Mathias ToftDepartment of Neurology, Oslo University Hospital, Oslo, Norway.ORCID 0000-0002-6723-6865
Lasse PihlstrømDepartment of Neurology, Oslo University Hospital, Oslo, Norway.
Leonor Correia GuedesInstituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
Joaquim J FerreiraInstituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.ORCID 0000-0003-3950-5113
Soraya BardienDivision of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa.ORCID 0000-0002-3508-3438
Jonathan CarrDivision of Neurology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa.
Eduardo TolosaParkinson's Disease & Movement Disorders Unit, Neurology Service, Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.ORCID 0000-0002-3781-0854
Mario EzquerraLab of Parkinson's disease and Other Neurodegenerative Movement Disorders, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain.ORCID 0000-0003-3246-6641
Pau PastorUnit of Neurodegenerative Diseases, Department of Neurology, University Hospital Germans Trias i Pujol, Barcelona, Spain.
Monica Diez-FairenFundació per la Recerca Biomèdica i Social Mútua Terrassa, Barcelona, Spain.
Karin WirdefeldtDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Nancy PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Caroline RanDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Andrea C BelinDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Andreas PuschmannLund University, Skåne University Hospital, Department of Clinical Sciences Lund, Neurology, Lund, Sweden.
Emil Ygland RödströmLund University, Skåne University Hospital, Department of Clinical Sciences Lund, Neurology, Lund, Sweden.
Carl E ClarkeUniversity of Birmingham and Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, United Kingdom.
Karen E MorrisonFaculty of Medicine, Health and Life Sciences, Queens University, Belfast, United Kingdom.
Manuela TanDepartment of Neurology, Oslo University Hospital, Oslo, Norway.ORCID 0000-0001-5835-669X
Dimitri KraincDepartment of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Lena F BurbullaGerman Center for Neurodegenerative Diseases, Tübingen, Germany.
Matt J FarrerDepartment of Neurology, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA.
Rejko KrugerTranslational Neuroscience, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-Belval, Luxembourg.
Thomas GasserDepartment for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, Tübingen, Germany.
Manu SharmaCentre for Genetic Epidemiology, Institute for Clinical Epidemiology and Applied Biometry, University of Tubingen, Tübingen, Germany.ORCID 0000-0002-1260-5416
Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease (Courage-PD) consortium
Thérèse TruongUniversité Paris-Saclay, UVSQ, Inserm, Gustave Roussy, Team "Exposome, Heredity, Cancer and Health", CESP, Villejuif, France.
Alexis ElbazUniversité Paris-Saclay, UVSQ, Inserm, Gustave Roussy, Team "Exposome, Heredity, Cancer and Health", CESP, Villejuif, France.ORCID 0000-0001-9724-5490
Inserm · FRCentre National de la Recherche Scientifique · FRCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRKarolinska Institutet · SENational Institutes of Health · USCentre international de recherche sur le cancer · FRGerman Center for Neurodegenerative Diseases · DEOslo University Hospital · NOUniversity of Toronto · CAAzienda Ospedaliera San Gerardo · ITCentre Hospitalier de Luxembourg · LUHelmholtz Zentrum München · DEJuntendo University · JPLund University · SEMagna Graecia University · ITNational and Kapodistrian University of Athens · GRNational Defense Medical College · JPNorthwestern University · USRadboud University Nijmegen · NLStellenbosch University · ZA

Funding

Translating Molecular and Clinical Data to Population Lung Cancer Risk AssessmentU19CA203654 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Rayjean J. Hung · 2017 to 2026
$23.7M
Characterizing Genetic Susceptibility to Breast and Prostate Cancer; the BPC3U01CA098758 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HENDERSON, BRIAN E · 2003 to 2010
$11.0M
Characterizing Genetic Susceptibility to Breast and Prostate Cancer; the BPC3U01CA098233 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI HUNTER, DAVID JOHN · 2003 to 2010
$10.8M
Epidemiologic StudiesU19CA148065 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI AHSAN, HABIBUL, BRUGGE, JOAN SIEFERT · 2010 to 2014
$10.6M
Epidemiological and Clinical Translational Studies Post Genome-Wide AssociationU19CA148537 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI EASTON, DOUGLAS FREDERICK, EELES, ROSALIND · 2010 to 2014
$10.4M
Ovarian cancer GWAS discovery, expansion and replication (N2 - Project #1)U19CA148112 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI SELLERS, THOMAS A · 2010 to 2014
$10.2M
Characterizing Genetic Susceptibility to Breast and Prostate Cancer; the BPC3U01CA098216 · NCI · INTERNATIONAL AGENCY FOR RES ON CANCER · PI RIBOLI, ELIO · 2003 to 2011
$7.4M
A genome-wide association study for breast cancer in BRCA1 mutation carriersR01CA128978 · NCI · MAYO CLINIC ROCHESTER · PI COUCH, FERGUS JOSEPH · 2008 to 2012
$4.8M
Characterizing Genetic Susceptibility to Breast and Prostate Cancer: The BPC3.U01CA098710 · NCI · AMERICAN CANCER SOCIETY, INC. · PI GAPSTUR, SUSAN M · 2003 to 2011
$4.2M
The contribution of RAD51C and RAD51D to breast and ovarian cancerR01CA225662 · NCI · MAYO CLINIC ROCHESTER · PI COUCH, FERGUS JOSEPH, WEROHA, SARAVUT · 2018 to 2024
$2.5M
Imputation-based approach to identify low frequency variants in prostate cancerU01CA188392 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SCHUMACHER, FREDRICK RAY · 2014 to 2016
$1.9M
Cancer Research UK A8197/A16565Cancer Research UK C12292/A11174Cancer Research UK C1281Cancer Research UK C1281/A12014Cancer Research UK C1287/A10118Cancer Research UK C1287/A10710Cancer Research UK C1287/A16563Cancer Research UK C16913/A6135Cancer Research UK C5047/A10692Cancer Research UK C5047/A33Cancer Research UK C5047/A3354Cancer Research UK C5047/A7357Cancer Research UK C5047/A8384Department of HealthNCI NIH HHS NIH NCI U01 CA188392NCI NIH HHS R01 CA128978NCI NIH HHS R01 CA225662NCI NIH HHS U01 CA098216NCI NIH HHS U01 CA098233NCI NIH HHS U01 CA098710NCI NIH HHS U01 CA098758NCI NIH HHS U01 CA188392NCI NIH HHS U19 CA148065NCI NIH HHS U19 CA148112NCI NIH HHS U19 CA148537NCI NIH HHS U19 CA203654NHGRI NIH HHSNHLBI NIH HHS HHSN268201200008CNHLBI NIH HHS HHSN268201200008INIH HHS CA128978NIH HHS NIH U19 CA203654NIH HHS U01-CA98233NIH HHS U01-CA98710NIH HHS X01HG007492Susan G. KomenWellcome Trust 209057World Health Organization 001
6 · The paper itself

Abstract

backgroundEpidemiological studies that examined the association between Parkinson's disease (PD) and cancers led to inconsistent results, but they face a number of methodological difficulties.

objectiveWe used results from genome-wide association studies (GWASs) to study the genetic correlation between PD and different cancers to identify common genetic risk factors.

methodsWe used individual data for participants of European ancestry from the Courage-PD (Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease; PD, N = 16,519) and EPITHYR (differentiated thyroid cancer, N = 3527) consortia and summary statistics of GWASs from iPDGC (International Parkinson Disease Genomics Consortium; PD, N = 482,730), Melanoma Meta-Analysis Consortium (MMAC), Breast Cancer Association Consortium (breast cancer), the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (prostate cancer), International Lung Cancer Consortium (lung cancer), and Ovarian Cancer Association Consortium (ovarian cancer) (N comprised between 36,017 and 228,951 for cancer GWASs). We estimated the genetic correlation between PD and cancers using linkage disequilibrium score regression. We studied the association between PD and polymorphisms associated with cancers, and vice versa, using cross-phenotypes polygenic risk score (PRS) analyses.

resultsWe confirmed a previously reported positive genetic correlation of PD with melanoma (G

conclusionsWe show evidence in favor of a contribution of pleiotropic genes to the association between PD and specific cancers. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.

Indexed as

Lung NeoplasmsMelanomaOvarian NeoplasmsParkinson DiseaseProstatic NeoplasmsFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMalePolymorphism, Single NucleotideRisk Factorscancergenetic correlationParkinson's diseasepleiotropypolygenic risk score

Identifiers

PMID36788297
PMCPMC10334300
OpenAlexW4320856410

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.