Evidence map›Paper›PMID 36788249›Full record

ArticleScientific data2023

A dataset of definitive endoderm and hepatocyte differentiations from human induced pluripotent stem cells.

Yuki Tanaka, Erina Furuhata, Shiori Maeda, Mami Kishima, Harukazu Suzuki, Takahiro Suzuki

Open access · goldAbstract readDataset
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific data, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yuki TanakaRIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.
Erina FuruhataRIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.
Shiori MaedaRIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.
Mami KishimaRIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.
Harukazu SuzukiRIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan. harukazu.suzuki@riken.jp.ORCID 0000-0002-8087-0836
Takahiro SuzukiRIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan. takahiro.suzuki.aa@riken.jp.ORCID 0000-0002-0972-6911
RIKEN Center for Integrative Medical Sciences · JP

Funding

Ministry of Education, Culture, Sports, Science and Technology (MEXT) 19K08852
6 · The paper itself

Abstract

Hepatocytes are a major parenchymal cell type in the liver and play an essential role in liver function. Hepatocyte-like cells can be differentiated in vitro from induced pluripotent stem cells (iPSCs) via definitive endoderm (DE)-like cells and hepatoblast-like cells. Here, we explored the in vitro differentiation time-course of hepatocyte-like cells. We performed methylome and transcriptome analyses for hepatocyte-like cell differentiation. We also analyzed DE-like cell differentiation by methylome, transcriptome, chromatin accessibility, and GATA6 binding profiles, using finer time-course samples. In this manuscript, we provide a detailed description of the dataset and the technical validations. Our data may be valuable for the analysis of the molecular mechanisms underlying hepatocyte and DE differentiations.

Indexed as

Cell DifferentiationInduced Pluripotent Stem CellsEndodermHepatocytesHumansLiver

Identifiers

PMID36788249
PMCPMC9929325
OpenAlexW4320857689

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.