Evidence map›Paper›PMID 36787751›Full record

ArticleNeuron2023

Brief synaptic inhibition persistently interrupts firing of fast-spiking interneurons.

Simon Chamberland, Erica R Nebet, Manuel Valero, Monica Hanani, Robert Egger, Samantha B Larsen, Katherine W Eyring, György Buzsáki, Richard W Tsien

Open access · hybridAbstract read
In one paragraph

Article in Neuron, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Dendritic Inhibition Terminates Plateau Potentials in CA1 Pyramidal Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Functional specialization of hippocampal somatostatin-expressing interneurons.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Simon ChamberlandNYU Neuroscience Institute and Department of Neuroscience and Physiology, NYU Langone Medical Center, New York, NY 10016, USA. Electronic address: simon.chamberland@nyulangone.org.
Erica R NebetNYU Neuroscience Institute and Department of Neuroscience and Physiology, NYU Langone Medical Center, New York, NY 10016, USA.
Manuel ValeroNYU Neuroscience Institute and Department of Neuroscience and Physiology, NYU Langone Medical Center, New York, NY 10016, USA.
Monica HananiNYU Neuroscience Institute and Department of Neuroscience and Physiology, NYU Langone Medical Center, New York, NY 10016, USA.
Robert EggerNYU Neuroscience Institute and Department of Otolaryngology, NYU Langone Medical Center, New York, NY 10016, USA; Center for Neural Science, New York University, New York, NY 10003, USA.
Samantha B LarsenNYU Neuroscience Institute and Department of Neuroscience and Physiology, NYU Langone Medical Center, New York, NY 10016, USA.
Katherine W EyringNYU Neuroscience Institute and Department of Neuroscience and Physiology, NYU Langone Medical Center, New York, NY 10016, USA.
György BuzsákiNYU Neuroscience Institute and Department of Neuroscience and Physiology, NYU Langone Medical Center, New York, NY 10016, USA; Center for Neural Science, New York University, New York, NY 10003, USA; Department of Neurology, Langone Medical Center, New York University, New York, NY, USA.
Richard W TsienNYU Neuroscience Institute and Department of Neuroscience and Physiology, NYU Langone Medical Center, New York, NY 10016, USA; Center for Neural Science, New York University, New York, NY 10003, USA. Electronic address: richard.tsien@nyulangone.org.
NYU Langone Health · US

Funding

U19 Supplement 2023-FroemkeU19NS107616 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RICHARD W TSIEN · 2018 to 2026
$36.4M
Towards a Complete Description of the Circuitry Underlying Sharp Wave-Mediated Memory ReplayU19NS104590 · NINDS · STANFORD UNIVERSITY · PI LISMAN, JOHN E · 2017 to 2021
$13.2M
Neuronal Adaptation and Plasticity after Chronic DisuseR01MH071739 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TSIEN, RICHARD W · 2015 to 2024
$5.5M
Brain rhythms-assisted memory enhancementR01MH107396 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BUZSAKI, GYORGY, DEVINSKY, ORRIN · 2015 to 2019
$3.3M
Postdoctoral Research Training in Neurodegenerative Disorders and the Aging BrainT32AG052909 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Helen E Scharfman, THOMAS M WISNIEWSKI · 2017 to 2026
$2.5M
Towards a Complete Description of the Circuitry Underlying Memory replay.U01NS090583 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI SOLTESZ, IVAN · 2014 to 2016
$2.1M
Calcium Channels, Calmodulin and Nuclear CREB SignalingR01DA040484 · NIDA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TSIEN, RICHARD W · 2015 to 2019
$2.0M
Synaptic and cellular mechanisms of neuronal synchronizationK99MH126157 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CHAMBERLAND, SIMON · 2021 to 2022
$245k
NIA NIH HHS T32 AG052909NIDA NIH HHS R01 DA040484NIMH NIH HHS K99 MH126157NIMH NIH HHS R01 MH071739NIMH NIH HHS R01 MH107396NINDS NIH HHS U01 NS090583NINDS NIH HHS U19 NS104590NINDS NIH HHS U19 NS107616
6 · The paper itself

Abstract

Neurons perform input-output operations that integrate synaptic inputs with intrinsic electrical properties; these operations are generally constrained by the brevity of synaptic events. Here, we report that sustained firing of CA1 hippocampal fast-spiking parvalbumin-expressing interneurons (PV-INs) can be persistently interrupted for several hundred milliseconds following brief GABA

Indexed as

Pyramidal CellsSynaptic TransmissionAction PotentialsInterneuronsSynaptic Membranesfast-spiking interneuronshippocampusinhibitionpersistent activity

Identifiers

PMID36787751
PMCPMC10121938
OpenAlexW4320487104

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.