Evidence map›Paper›PMID 36787663›Full record

ArticleGeriatric nursing (New York, N.Y.)

Brain predicted age difference mediates pain impact on physical performance in community dwelling middle to older aged adults.

Jessica A Peterson, Alisa Johnson, Chavier Laffitte Nordarse, Zhiguang Huo, James Cole, Roger B Fillingim, Yenisel Cruz-Almeida

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Geriatric nursing (New York, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Jessica A PetersonPain Research and Intervention Center of Excellence, University of Florida, Gainesville, FL, USA; Department of Community Dentistry and Behavioral Science, University of Florida, Gainesville, FL 32610, USA.
Alisa JohnsonPain Research and Intervention Center of Excellence, University of Florida, Gainesville, FL, USA; Department of Community Dentistry and Behavioral Science, University of Florida, Gainesville, FL 32610, USA.
Chavier Laffitte NordarsePain Research and Intervention Center of Excellence, University of Florida, Gainesville, FL, USA; Department of Community Dentistry and Behavioral Science, University of Florida, Gainesville, FL 32610, USA.
Zhiguang HuoDepartment of Biostatistics, University of Florida, Gainesville, FL, USA.
James ColeCentre for Medical Image Computing, Department of Computer Science, University College London, London, UK; Psychology and Neuroscience, King's College London, Institute of Psychiatry, London, UK; Dementia Research Centre, Institute of Neurology, University College London, London, UK.
Roger B FillingimPain Research and Intervention Center of Excellence, University of Florida, Gainesville, FL, USA; Department of Community Dentistry and Behavioral Science, University of Florida, Gainesville, FL 32610, USA.
Yenisel Cruz-AlmeidaPain Research and Intervention Center of Excellence, University of Florida, Gainesville, FL, USA; Department of Community Dentistry and Behavioral Science, University of Florida, Gainesville, FL 32610, USA. Electronic address: cryeni@ufl.edu.
University of Florida · USUniversity College London · GB

Funding

National Dissemination of I-Corps@NCATS: Accelerating Translation through CommercializationUL1TR003096 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GUTIERREZ, ORLANDO M, KIMBERLY, ROBERT P. · 2019 to 2023
$43.6M
University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Peihua Qiu · 2007 to 2026
$22.8M
Ethnic Differences in Responses to Painful StimuliR37AG033906 · NIA · UNIVERSITY OF FLORIDA · PI FILLINGIM, ROGER B · 2014 to 2023
$12.9M
Supplement-Discovery and Validation of Epigenetic Biomarkers in Brain TissueR01AG067757 · NIA · UNIVERSITY OF FLORIDA · PI CRUZ-ALMEIDA, YENISEL · 2020 to 2024
$4.2M
Diversity Supplement for Kristina Bell: Biopsychosocial pain predictors of mobility decline in agingR01AG076082 · NIA · UNIVERSITY OF FLORIDA · PI Stephen Coombes, Yenisel Cruz-Almeida · 2022 to 2026
$3.1M
Mechanisms of Oxytocin's Analgesia in Older Adults (Diversity Supplement)R01AG059809 · NIA · UNIVERSITY OF FLORIDA · PI CRUZ-ALMEIDA, YENISEL, EBNER, NATALIE C · 2018 to 2022
$1.8M
Medical Research Council MR/R024790/1Medical Research Council MR/R024790/2NCATS NIH HHS UL1 TR003096NIA NIH HHS P30 AG028740NIA NIH HHS R01 AG059809NIA NIH HHS R01 AG067757NIA NIH HHS R01 AG076082NIA NIH HHS R37 AG033906
6 · The paper itself

Abstract

The purpose of the study was to examine associations between physical performance and brain aging in individuals with knee pain and whether the association between pain and physical performance is mediated by brain aging. Participants (n=202) with low impact knee pain (n=111), high impact knee pain (n=60) and pain-free controls (n=31) completed self-reported pain, magnetic resonance imaging (MRI), and a Short Physical Performance Battery (SPPB) that included balance, walking, and sit to stand tasks. Brain predicted age difference, calculated using machine learning from MRI images, significantly mediated the relationships between walking and knee pain impact (CI: -0.124; -0.013), walking and pain-severity (CI: -0.008; -0.001), total SPPB score and knee pain impact (CI: -0.232; -0.025), and total SPPB scores and pain-severity (CI: -0.019; -0.001). Brain-aging begins to explain the association between pain and physical performance, especially walking. This study supports the idea that a brain aging prediction can be calculated from shorter duration MRI sequences and possibly implemented in a clinical setting to be used to identify individuals with pain who are at risk for accelerated brain atrophy and increased likelihood of disability.

Indexed as

AgingIndependent LivingAdultBrainHumansMiddle AgedPainPhysical Functional PerformanceAgingKnee osteoarthritisKnee painMobilityNeuroimagingPhysical performance

Identifiers

PMID36787663
PMCPMC10360023
OpenAlexW4320186785

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.