Evidence map›Paper›PMID 36787362›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

1700029I15Rik orchestrates the biosynthesis of acrosomal membrane proteins required for sperm-egg interaction.

Yonggang Lu, Kentaro Shimada, Shaogeng Tang, Jingjing Zhang, Yo Ogawa, Taichi Noda, Hiroki Shibuya, Masahito Ikawa

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
7.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. The SPARK complex forms the molecular basis of vertebrate fertilization.bioRxiv : the preprint server for biology · 2026
    Article
  4. Membrane Fusions During Mammalian Fertilization.Advances in experimental medicine and biology · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Allosteric inhibition of the IZUMO1-JUNO fertilization complex by the naturally occurring antisperm antibody OBF13.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Spatial Organization of the Sperm Cell Glycoproteome.Molecular & cellular proteomics : MCP · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 3 countries.

Yonggang LuImmunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan.ORCID 0000-0003-0198-8906
Kentaro ShimadaDepartment of Experimental Genome Research, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan.
Shaogeng TangSarafan ChEM-H, Stanford University, Stanford, CA 94305.ORCID 0000-0002-3904-492X
Jingjing ZhangDepartment of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg SE-41390, Sweden.
Yo OgawaDepartment of Experimental Genome Research, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan.
Taichi NodaDepartment of Experimental Genome Research, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan.ORCID 0000-0003-0260-7861
Hiroki ShibuyaDepartment of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg SE-41390, Sweden.ORCID 0000-0002-3400-0741
Masahito IkawaImmunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan.ORCID 0000-0001-9859-6217
Osaka University of Pharmaceutical Sciences · JPUniversity of Gothenburg · SEKumamoto University · JPStanford University · USSystems Biology Institute · JPThe University of Osaka · JP

Funding

Targeting sperm-specific proteins during meiosis and sperm morphogenesisP01HD087157 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI GARCIA, THOMAS · 2017 to 2021
$6.2M
Functional analysis of novel testis-expressed secreted and transmembrane proteinsR01HD088412 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MARTIN M. MATZUK · 2016 to 2026
$4.5M
Cell Surface Receptor Recognition and Membrane Fusion in Mammalian FertilizationK99HD104924 · NICHD · STANFORD UNIVERSITY · PI TANG, SHAOGENG · 2021 to 2022
$383k
NICHD NIH HHS K99 HD104924NICHD NIH HHS P01 HD087157NICHD NIH HHS R01 HD088412
6 · The paper itself

Abstract

Sperm acrosomal membrane proteins, such as Izumo sperm-egg fusion 1 (IZUMO1) and sperm acrosome-associated 6 (SPACA6), play essential roles in mammalian gamete binding or fusion. How their biosynthesis is regulated during spermiogenesis has largely remained elusive. Here, we show that

Indexed as

AcrosomeMembrane ProteinsAnimalsMaleMammalsMiceMice, KnockoutOvumSemenSeminal Plasma ProteinsSpermatozoaSperm-Ovum InteractionsMembrane ProteinsSeminal Plasma ProteinsSpaca6 protein, mouse1700029I15RikC11orf94/Freyfertilizationmale infertilitysperm–egg fusion

Identifiers

PMID36787362
PMCPMC9974436
OpenAlexW4320709603

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.