Evidence map›Paper›PMID 36787356›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

A cryptic oxidoreductase safeguards oxidative protein folding in

Melissa E Reardon-Robinson, Minh Tan Nguyen, Belkys C Sanchez, Jerzy Osipiuk, Christian Rückert, Chungyu Chang, Bo Chen, Rahul Nagvekar, Andrzej Joachimiak, Andreas Tauch and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Melissa E Reardon-RobinsonDepartment of Microbiology & Molecular Genetics, University of Texas McGovern Medical School, Houston, TX 77030.
Minh Tan NguyenDivision of Oral and Systemic Health Sciences, School of Dentistry, University of California, Los Angeles, CA 90095.
Belkys C SanchezDepartment of Microbiology & Molecular Genetics, University of Texas McGovern Medical School, Houston, TX 77030.
Jerzy OsipiukCenter for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL 60637.
Christian RückertCenter for Biotechnology, Bielefeld University, D-33615 Bielefeld, Germany.
Chungyu ChangDivision of Oral and Systemic Health Sciences, School of Dentistry, University of California, Los Angeles, CA 90095.ORCID 0000-0001-6127-3086
Bo ChenDepartment of Microbiology & Molecular Genetics, University of Texas McGovern Medical School, Houston, TX 77030.
Rahul NagvekarDepartment of Microbiology & Molecular Genetics, University of Texas McGovern Medical School, Houston, TX 77030.
Andrzej JoachimiakCenter for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL 60637.
Andreas TauchCenter for Biotechnology, Bielefeld University, D-33615 Bielefeld, Germany.
Asis DasDepartment of Medicine, Neag Comprehensive Cancer Center, University of Connecticut Health Center, Farmington, CT 06030.
Hung Ton-ThatDivision of Oral and Systemic Health Sciences, School of Dentistry, University of California, Los Angeles, CA 90095.ORCID 0000-0003-1611-0469
University of California, Los Angeles · USArgonne National Laboratory · USBielefeld University · DEBaylor College of Medicine · USStanford University · USUConn Health · US

Funding

TO PROVIDE SCIENTIFIC SUPPORT TO THE CENTERS FOR RESEARCH ON STRUCTURAL BIOLOGY OF INFECTIOUS DISEASES.75N93022C00035 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SATCHELL, KARLA · 2022 to 2025
$20.7M
Post-translocational protein folding in Gram-positive bacteriaR01DE025015 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI TON-THAT, HUNG · 2015 to 2024
$3.9M
Molecular Basis of Infectious Diseases Training GrantT32AI055449 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LORENZ, MICHAEL C · 2005 to 2025
$2.6M
Oxidative protein folding of pilins and virulence in Gram-positive bacteriaF31DE024004 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ROBINSON, MELISSA ELIZABETH · 2013 to 2014
$59k
NIAID NIH HHS 75N93022C00035NIAID NIH HHS HHSN272201700060CNIAID NIH HHS T32 AI055449NIDCR NIH HHS F31 DE024004NIDCR NIH HHS R01 DE025015
6 · The paper itself

Abstract

In many gram-positive Actinobacteria, including

Indexed as

Bacterial ProteinsCorynebacterium diphtheriaeProtein Disulfide Reductase (Glutathione)Protein FoldingOxidative StressBacterial ProteinsProtein Disulfide Reductase (Glutathione)Corynebacterium diphtheriaediphtheria toxindisulfide bondgram-positive bacteriapili

Identifiers

PMID36787356
PMCPMC9974433
OpenAlexW4320709301

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.