ArticlePloS one2023
Mental health, cancer risk, and the mediating role of lifestyle factors in the CARTaGENE cohort study.
Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Exposing the Influence of Preceding Sexual Behavior in Younger Years toward Prostate Cancer Occurrence: Qualitative Mapping on Sexual Risk Factors.Asian Pacific journal of cancer prevention : APJCP · 2025Pooled it
- Mental Health Conditions and Incident Cancer: A Prospective Cohort Study of 402,255 UK Biobank Participants.International journal of cancer · 2026Article
- Associations between psychological distress and thyroid cancer, and the mediating role of lifestyle and metabolism: a cohort study from the UK Biobank.Frontiers in oncology · 2026Article
- Does health insurance coverage improve cardiometabolic risk factor levels? Quasi-experimental evidence from India.Global health action · 2025Article
- Emergency colon cancer diagnosis in people with mental health conditions: a population-based cohort study in northern Italy.BMJ mental health · 2025Article
- Association Between Suicidal Ideation and Cancer Screening Uptake: Results from Middle-Aged and Older Adults in Korea.Cancers · 2025Article
- Regression and machine learning approaches identify potential risk factors for glioblastoma multiforme.Brain communications · 2025Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEvidence on the association between mental health disorders and cancer risk is inconclusive, despite well-established associations between mental health disorders and lifestyle factors such as smoking. This study examines the relationships between depression, anxiety and cancer risk, and the potential mediating effects of lifestyle factors.
methodsA study of 34,571 participants aged 40-69 years in the CARTaGENE cohort was conducted. Depression was defined by questionnaire (PHQ-9), antidepressant use, and a composite of questionnaire, antidepressant use, or lifetime self-reported physician diagnosis. Anxiety was defined by questionnaire (GAD-7). Co-morbid depression and anxiety was also assessed. Cox regression models were used to investigate associations between mental health and risk of prostate, lung, and all cancers combined. Mediating effects of lifestyle factors were assessed using Baron and Kenny mediation criteria.
resultsThere were positive associations between mental health disorders, all cancers and lung cancer risk, however with the exception of anxiety and lung cancer in women (Hazard Ratio [HR] = 1.67, 95% CI: 1.01-2.76), associations were attenuated with adjustment for sociodemographics, health status and lifestyle factors. In the mediation analysis, smoking accounted for 27%, 18%, and 26%, of the total effect between depression (PHQ-9), anxiety, and co-morbidity and lung cancer, respectively in women. In men, smoking accounted for 17% of the total effect between depression (PHQ-9, antidepressant, or lifetime self-report of physician diagnosis) and all cancers.
conclusionsPositive associations were observed between mental health disorders, all cancer and lung cancer risk, however most relationships were attenuated with adjustment for lifestyle factors. Smoking status mediated a significant proportion of the relationships between mental health disorders and cancer risk.
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