Evidence map›Paper›PMID 36787086›Full record

ArticleInternational urology and nephrology2023

Glomerular deposition of fibrinogen predicts good prognosis of IgA nephropathy: a single-center cohort study.

Wei-Guang Yang, Rong Zhu, Jian-Nan Zheng, Jun-Xiao Zhang, Nan Liu, Li Yao, Lin-Lin Liu

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In one paragraph

Article in International urology and nephrology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 0 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Wei-Guang Yang *Department of Nephrology, The First Affiliated Hospital of China Medical University, 155 Nan Jing North Street, He Ping District, Shen Yang, 110001, Liao Ning, China.
Rong Zhu *Department of Nephrology, The First Affiliated Hospital of China Medical University, 155 Nan Jing North Street, He Ping District, Shen Yang, 110001, Liao Ning, China.
Jian-Nan ZhengDepartment of Nephrology, The First Affiliated Hospital of China Medical University, 155 Nan Jing North Street, He Ping District, Shen Yang, 110001, Liao Ning, China.
Jun-Xiao ZhangDepartment of Nephrology, The First Affiliated Hospital of China Medical University, 155 Nan Jing North Street, He Ping District, Shen Yang, 110001, Liao Ning, China.
Nan LiuDepartment of Nephrology, The First Affiliated Hospital of China Medical University, 155 Nan Jing North Street, He Ping District, Shen Yang, 110001, Liao Ning, China.
Li YaoDepartment of Nephrology, The First Affiliated Hospital of China Medical University, 155 Nan Jing North Street, He Ping District, Shen Yang, 110001, Liao Ning, China.
Lin-Lin LiuDepartment of Nephrology, The First Affiliated Hospital of China Medical University, 155 Nan Jing North Street, He Ping District, Shen Yang, 110001, Liao Ning, China. catherine-ll@126.com.ORCID http://orcid.org/0000-0002-5283-8636
China Medical University · CN

Funding

National Natural Science Foundation of China 81500525National Natural Science Foundation of China 81970617Natural Science Foundation of Liaoning Province 2019-MS-367Special fund for clinical research of Chinese Medical University 18020060785
6 · The paper itself

Abstract

purposeIt has been proven that fibrinogen deposition exists in IgA nephropathy (IgAN), but its clinical significance has not been identified. We aim to investigate the clinical implication of fibrinogen deposition in evaluating the activity and prognosis of IgA nephropathy.

methodsIn this cohort, 935 adult IgAN patients were divided into 3 groups according to the intensity of glomerular fibrinogen deposition. Primary outcome refers to a composite event of either a ≥ 50% reduction in eGFR or ESRD (eGFR < 15 ml/min/1.73m2, dialysis, or renal transplantation). Factors associated with fibrinogen deposition and prognosis were identified.

resultsThe results showed that the intensity of fibrinogen deposition was positively correlated with eGFR (P < 0.001), serum albumin (P = 0.041), and hemoglobin levels (P < 0.05), but negatively correlated with age (P = 0.04), serum fibrinogen levels (P < 0.001), serum C4 (P = 0.023), the proportion of patients with hypertension (P = 0.003), and the percentage of glomeruli sclerosis (P < 0.001). The prognostic analyses identified that fibrinogen deposition was an independent predictor for the progression of IgAN (P = 0.033).

conclusionOur study indicated that the deposition of renal fibrinogen can predict the prognosis of IgAN with high reliability.

Indexed as

Glomerulonephritis, IGAAdultCohort StudiesDisease ProgressionFibrinogenGlomerular Filtration RateHumansPrognosisReproducibility of ResultsRetrospective StudiesFibrinogenFibrinogen depositionIgA nephropathyPredictorPrognosis

Identifiers

PMID36787086
PMCPMC10293415
OpenAlexW4320709477

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.