Fully automatic carotid arterial stiffness assessment from ultrasound videos based on machine learning.

Arterial stiffness (AS) refers to the loss of arterial compliance and alterations in vessel wall properties. The study of local carotid stiffness (CS) is particularly important since carotid artery stiffening raises the risk of stroke, cognitive impairment, and dementia. So, stiffness measurement as a screening tool approach is crucial because it can reduce mortality and facilitate therapy planning. This study aims to evaluate the stiffness of the CCA using machine learning (ML) through the features of diameter change (ΔD) and stiffness parameters. This study was conducted in seven stages: data collection, preprocessing, CCA segmentation, CCA lumen diameter (DCCA) computing during cardiac cycles, denoising signals of DCCA, computational of AS parameters, and stiffness assessment using ML. The 51 videos (with 25 s) of CCA B-mode ultrasound (US) were used and analyzed. Each US video yielded approximately 750 sequential frames spanning about 24 cardiac cycles. Firstly, US preset settings with time gain compensation with a U-pattern were employed to enhance CCA segmentations. The study showed that auto region-growing, employed three times, is appropriate for segmenting walls with a short running time (4.56 s/frame). The diameter computed for frames constructs a signal (diameter signal) with noisy parts in the shape of peak variance and an un-smooth side. Among the 12 employed smoothing methods, spline fitting with a mean peak difference per cycle (MPDCY) of 0.58 pixels was the most effective for the diameter signal. The authors propose the MPDCY as a new selection criterion for smoothing methods with highly preserved peaks. The ΔD (D