Evidence map›Paper›PMID 36786964›Full record

ArticleBiological trace element research2023

Selenium Deficiency via the ROS/NLRP3/IL-1β Signaling Pathway Leads to Pyroptosis Injury in Pig Spleen.

Lichao Song, Zhihui Jiang, Xingwang Zhang, Yuwei Song, Yueteng Xing, Guodong Wang

Abstract read
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In one paragraph

Article in Biological trace element research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. The protective effects of selenium against NLRP3-mediated inflammation and pyroptosis: mechanisms and the potential health benefits.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Review
  2. Review
  3. iMeta · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Lichao SongHenan Provincial Key Laboratory of Subcritical High-Efficiency Extraction, Anyang Institute of Technology, Huanghe Rd. 20, Anyang, 455000, Henan, China.
Zhihui JiangHenan Provincial Key Laboratory of Subcritical High-Efficiency Extraction, Anyang Institute of Technology, Huanghe Rd. 20, Anyang, 455000, Henan, China. jiangzhihui19870326@126.com.
Xingwang ZhangHenan Provincial Key Laboratory of Subcritical High-Efficiency Extraction, Anyang Institute of Technology, Huanghe Rd. 20, Anyang, 455000, Henan, China.
Yuwei SongHenan Provincial Key Laboratory of Subcritical High-Efficiency Extraction, Anyang Institute of Technology, Huanghe Rd. 20, Anyang, 455000, Henan, China.
Yueteng XingHenan Provincial Key Laboratory of Subcritical High-Efficiency Extraction, Anyang Institute of Technology, Huanghe Rd. 20, Anyang, 455000, Henan, China.
Guodong WangHenan Provincial Key Laboratory of Subcritical High-Efficiency Extraction, Anyang Institute of Technology, Huanghe Rd. 20, Anyang, 455000, Henan, China.
Anyang Institute of Technology · CN

Funding

Natural Science Foundation of China 32102744Natural Science Foundation of Henan Province 202300410008
6 · The paper itself

Abstract

The aim of the present study was to investigate the effect of selenium (Se) deficiency on the relationship between the pyroptosis and MAPK signaling pathway in spleen injury. A total of 10 two-month-old Sus scrofa domesticus specimens were allocated to two groups. The control group was fed a basal diet (0.15-mg/kg Se), and the experimental group was fed a 0.03-mg/kg Se-deficient diet for 2 months. The pig-spleen histopathological changes were observed with hematoxylin-eosin staining. Frozen sections were prepared to detect the content of ROS in pig-spleen cells. The oxidation stress related indexes were determined using a spectrophotometer. The levels of pyroptosis- and MAPK signaling pathway-related factors were detected via quantitative real-time polymerase chain reaction (qPCR) and western blotting (WB). The results of sections showed that the lymphocytes decreased in number, the spacing of cells widened, and some cells were necrotic in the spleen tissue of pigs fed a low-selenium diet. The content of ROS, malondialdehyde, nitric oxide, H

Indexed as

PyroptosisSeleniumHydrogen PeroxideNF-E2-Related Factor 2NLR Family, Pyrin Domain-Containing 3 ProteinProto-Oncogene Proteins c-aktReactive Oxygen SpeciesSignal TransductionSpleenHydrogen PeroxideNF-E2-Related Factor 2NLR Family, Pyrin Domain-Containing 3 ProteinProto-Oncogene Proteins c-aktReactive Oxygen SpeciesSeleniumInflammationOxidative stressPyroptosisSeleniumSpleen

Identifiers

PMID36786964
OpenAlexW4320709892

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.