ArticleOral radiology2023
Evaluation of the effect of antiepileptic drugs on mandibular bone quality by fractal analysis.
Article in Oral radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Fractal analysis in dentistry: a bibliometric analysis (1991-2024).Oral radiology · 2026Article
- Individuals diagnosed with epilepsy: a fractal analysis and radiomorphometric evaluation.BMC oral health · 2026Article
- Evaluation of mandibular bone quality with respect to enzyme inducement potential of antiepileptic drugs via fractal analysis.BMC oral health · 2025Article
- Effects of Different Treatment Methods Used in Patients with Rheumatoid Arthritis on the Trabecular and Cortical Structure of the Mandible.Diagnostics (Basel, Switzerland) · 2025Article
- Evaluation of fractal analysis and radiomorphometric measurements of mandibular bone structure in bruxism and non-bruxism paediatric patients.Oral radiology · 2025Article
- The Effect of Chronic Swimming Exercise and Vitamin E Supplementation on Bone Element Metabolism in Epileptic Rats.Noro psikiyatri arsivi · 2024Article
- Evaluation of cortical and trabecular bone structure of the mandible in patients using L-Thyroxine.BMC oral health · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAntiepileptic drugs (AEDs) are used to control seizures in epilepsy and their long-term use is common. AED use has been associated with decreased bone mineral density. The aim of this study is to determine the effect of AEDs on mandibular bone quality using fractal analysis and panoramic morphometric indices.
methodsIn this study, dental and medical records of 132 patients (66 AED users and 66 control group) were used. Fractal analysis (FA), the panoramic mandibular index (PMI), mandibular cortical width (MCW), and Klemetti index (KI) measurements were performed on panoramic radiographs.
resultsIn all metrics, the mean values of the study group were significantly lower than the control group (p < 0.000). There is a statistically significant difference between the study and control groups in terms of KI distribution (p < 0.000). The mean fractal dimension (FD) values in each measured region of the female patients in the study group were found to be significantly lower than the female patients in the control group (p < 0.05). The mean FD values measured in ROI-2 and ROI-3 of male patients in the study group were found to be significantly lower than male patients in the control group (p < 0.05).
conclusionThe side effects of AEDs on bone metabolism were shown in this study. Dentists examining patients with epilepsy should be careful about osteoporotic changes in the jaws.
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