Trial reportBreast cancer research and treatment2023
Effects of preoperative magnetic resonance image on survival rates and surgical planning in breast cancer conservative surgery: randomized controlled trial (BREAST-MRI trial).
Trial report in Breast cancer research and treatment, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- PROMRIINE (PRe-operatory Magnetic Resonance Imaging is INEffective) Study: A Systematic Review and Meta-analysis of the Impact of Magnetic Resonance Imaging on Surgical Decisions and Clinical Outcomes in Women with Breast Cancer.Annals of surgical oncology · 2024Pooled it
- Rethinking Preoperative MRI in Early Breast Cancer: Who Truly Benefits?European journal of breast health · 2026Article
- Breast-Conserving Surgery in Multicentric Breast Cancer: Evolving Evidence and Patient Selection.Cancers · 2026Review
- Fewer breast cancers during post-treatment surveillance among patients initially staged using contrast-based imaging.Breast cancer research and treatment · 2026Article
- Impact of preoperative MRI on long-term outcomes of breast-conserving therapy with electronic kV-intraoperative radiotherapy: A risk-stratified analysis based on ASTRO criteria.Breast (Edinburgh, Scotland) · 2026Article
- Survey of the Senologic International Society (SIS) on the Use of Preoperative Breast MRI in Early-Stage Breast Cancer: A Global Perspective on Current Practice.European journal of breast health · 2026Article
- Trends in use of magnetic resonance imaging and partial breast irradiation between 2011-2022 in the Netherlands: A population-based study.Clinical and translational radiation oncology · 2025Article
- Laser-induced breakdown spectroscopy for lithium-mediated cancer cell detection and ablation.Lasers in medical science · 2025Article
- Monitoring Pharmacological Treatment of Breast Cancer with MRI.Current issues in molecular biology · 2025Review
- Deep Learning-Based DCE-MRI Automatic Segmentation in Predicting Lesion Nature in BI-RADS Category 4.Journal of imaging informatics in medicine · 2025Article
- Preoperative breast MRI reduces reoperations for unilateral invasive lobular carcinoma: a patient-matched analysis from the MIPA study.European radiology · 2025Observational
- AI-CAD-Guided Mammographic Assessment of Tumor Size and T Stage: Concordance with MRI for Clinical Staging in Breast Cancer Patients Considered for NAC.Tomography (Ann Arbor, Mich.) · 2025Article
- The influencing factors and prognosis analysis of positive initial margin in intraoperative frozen section during breast-conserving surgery.European journal of medical research · 2025Article
- Magnetic resonance imaging characteristics and survival outcomes of metaplastic breast carcinoma.PloS one · 2025Article
- Impact of adding preoperative magnetic resonance imaging to ultrasonography on male breast cancer survival: a matched analysis with female breast cancer.Ultrasonography (Seoul, Korea) · 2025Article
- Addressing Discrepant Clinical Practice Patterns in Preoperative Breast MRI Use.Radiology. Imaging cancer · 2024Article
- ASO Author Reflection: Reevaluating the Role of Preoperative MRI in Breast Cancer Surgery: Lessons Learned and Future Directions.Annals of surgical oncology · 2024Article
- Contrast-Enhanced Mammography in Local Staging of Screen-Detected Breast Cancer.Annals of surgical oncology · 2024Article
- Reliability of Kaiser Score in Assessing Additional Breast Lesions Identified on Staging MRI in Patients with Breast Cancer.Diagnostics (Basel, Switzerland) · 2024Article
- Investigation of symptom management and functional state of women who underwent breast cancer surgery.Revista da Associacao Medica Brasileira (1992) · 2024Article
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBreast magnetic resonance imaging (MRI) has high sensitivity in detecting invasive neoplasms. Controversy remains about its impact on the preoperative staging of breast cancer surgery. This study evaluated survival and surgical outcomes of preoperative MRI in conservative breast cancer surgery.
methodsA phase III, randomized, open-label, single-center trial including female breast cancer participants, stage 0-III disease, and eligible for breast-conserving surgery. We compared the role of including MRI in preoperative evaluation versus radiologic exam routine with mammography and ultrasound in breast cancer conservative candidates. The primary outcome was local relapse-free survival (LRFS), and secondary outcomes were overall survival (OS), mastectomy rate, and reoperation rate.
results524 were randomized to preoperative MRI group (n = 257) or control group (n = 267). The survival analysis showed a 5.9-years LRFS of 99.2% in MRI group versus 98.9% in control group (HR = 0.72; 95% CI 0.12-4.28; p = 0.7) and an OS of 95.3% in the MRI group versus 96.3% in the control group (HR = 1.37 95% CI 0.59-3.19; p = 0.8). Surgical management changed in 21 ipsilateral breasts in the MRI group; 21 (8.3%) had mastectomies versus one in the control group. No difference was found in reoperation rates, 22 (8.7%) in the MRI group versus 23 (8.7%) in the control group (RR = 1.002; 95% CI 0.57-1.75; p = 0.85).
conclusionPreoperative MRI increased the mastectomy rates by 8%. The use of preoperative MRI did not influence local relapse-free survival, overall survival, or reoperation rates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.