Evidence map›Paper›PMID 36786893›Full record

ArticleResearch on child and adolescent psychopathology2023

The Impact of Early and Recent Life Stress on Trajectories of Inflammatory Biomarkers in a Diverse Sample of Adolescents.

Marin M Kautz, Brae Anne McArthur, Daniel P Moriarity, Lauren M Ellman, Joshua Klugman, Christopher L Coe, Lyn Y Abramson, Lauren B Alloy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Research on child and adolescent psychopathology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Annual Research Review: Neuroimmune network model of depression: a developmental perspective.Journal of child psychology and psychiatry, and allied disciplines · 2024
    Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marin M KautzDepartment of Psychology and Neuroscience, Temple University, Weiss Hall, 1701 N. 13th St., Philadelphia, PA, 19122, USA.
Brae Anne McArthurDepartment of Psychology, University of Calgary, Alberta, Canada.
Daniel P MoriarityDepartment of Psychology and Neuroscience, Temple University, Weiss Hall, 1701 N. 13th St., Philadelphia, PA, 19122, USA.
Lauren M EllmanDepartment of Psychology and Neuroscience, Temple University, Weiss Hall, 1701 N. 13th St., Philadelphia, PA, 19122, USA.
Joshua KlugmanDepartment of Psychology and Neuroscience, Temple University, Weiss Hall, 1701 N. 13th St., Philadelphia, PA, 19122, USA.
Christopher L CoeDepartment of Psychology, University of Wisconsin-Madison, Wisconsin, USA.
Lyn Y AbramsonDepartment of Psychology, University of Wisconsin-Madison, Wisconsin, USA.
Lauren B AlloyDepartment of Psychology and Neuroscience, Temple University, Weiss Hall, 1701 N. 13th St., Philadelphia, PA, 19122, USA. lalloy@temple.edu.

Funding

Integrated Reward-Inflammation Model Of First Onset Of Major Depression In Adolescence SupplementR01MH123473 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI ALLOY, LAUREN BERSH, NUSSLOCK, ROBIN · 2021 to 2025
$3.8M
Depression Surge in Adolescence & Gender Differences: Biocognitive MechanismsR01MH079369 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI ABRAMSON, LYN Y, ALLOY, LAUREN BERSH · 2008 to 2012
$3.4M
Risk for Adolescent Depression: Stress, Cognitive Vulnerability, & InflammationR01MH101168 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI ALLOY, LAUREN BERSH · 2013 to 2017
$3.2M
Testing a Social Safety Theory Perspective on Depression: An Intensive Longitudinal Immunopsychiatric Data ApproachF32MH130149 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MORIARITY, DANIEL P · 2022 to 2024
$210k
NIMH NIH HHS F32 MH130149NIMH NIH HHS MH079369NIMH NIH HHS MH101168NIMH NIH HHS MH123473NIMH NIH HHS R01 MH079369NIMH NIH HHS R01 MH101168NIMH NIH HHS R01 MH123473
6 · The paper itself

Abstract

Elevated inflammatory activity is one possible pathway through which exposure to childhood adversity engenders risk for physical and psychiatric illnesses. Limited research has investigated the compounding effects of childhood and adolescent stress exposure on changes in circulating levels of inflammatory biomarkers. This study assessed whether childhood adversity interacted with chronic or acute stress during adolescence to affect the temporal trajectories of five inflammatory biomarkers across at least three blood draws in a diverse sample of adolescents (N = 134; observations = 462). Using multilevel modeling, the interaction of childhood adversity, time, and within-person variance of acute stressors significantly predicted trajectories of higher interleukin-10 levels, controlling for demographics, medication use, and body mass index. Adolescents with high levels of childhood adversity who were exposed to a higher frequency of acute stressors compared to their own average rate of stress exposure consistently had higher levels of IL-10 as they got older, but those with average and below frequency of acute stressors had decreasing trajectories of log IL-10 as they matured. The results demonstrate how events early in life shape biological responses to the adolescent environment. This study also highlights the importance of developmental timing on the body's enhanced reactivity to acute and sustained stressors following childhood adversity.

Indexed as

Interleukin-10Mental DisordersAdolescentBiomarkersHumansLife Change EventsStress, PsychologicalBiomarkersInterleukin-10AdolescenceChildhood adversityInflammationStressful life events

Identifiers

PMID36786893
PMCPMC10642298

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.