Evidence map›Paper›PMID 36786859›Full record

ReviewPediatric nephrology (Berlin, Germany)2023

Diagnosis and management of mineral and bone disorders in infants with CKD: clinical practice points from the ESPN CKD-MBD and Dialysis working groups and the Pediatric Renal Nutrition Taskforce.

Justine Bacchetta, Claus Peter Schmitt, Sevcan A Bakkaloglu, Shelley Cleghorn, Maren Leifheit-Nestler, Agnieszka Prytula, Bruno Ranchin, Anne Schön, Stella Stabouli, Johan Van de Walle and 3 more

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pediatric nephrology (Berlin, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Early and Stage-Dependent Cardiopulmonary Fitness Impairment in Pediatric CKD.Clinical journal of the American Society of Nephrology : CJASN · 2026
    Article
  5. Review
  6. Observational
  7. Bone turnover markers in the management of CKD-associated osteoporosis-a European consensus.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026
    Review
  8. Review
  9. Article
  10. Review
  11. Management of rickets: the new horizons for the pediatrician.Journal of health, population, and nutrition · 2025
    Review
  12. Review
  13. Chronic kidney disease.Nature reviews. Disease primers · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 7 countries.

Justine BacchettaReference Center for Rare Renal Diseases, Reference Center for Rare Diseases of Calcium and Phosphate Metabolism, Pediatric Nephrology Rheumatology and Dermatology Unit, Hopital Femme Mère Enfant, Boulevard Pinel, 69677, Bron, France.ORCID http://orcid.org/0000-0002-0578-2529
Claus Peter SchmittCenter for Pediatric and Adolescent Medicine, Im Neuenheimer Feld 430, 69120, Heidelberg, Germany.
Sevcan A BakkalogluDepartment of Pediatric Nephrology, School of Medicine, Gazi University, Ankara, Turkey.
Shelley CleghornRenal Unit, UCL Great Ormond Street Hospital and Institute of Child Health, London, UK.
Maren Leifheit-NestlerDepartment of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Pediatric Research Center, Hannover, Germany.
Agnieszka PrytulaDepartment of Pediatric Nephrology and Rheumatology, Ghent University Hospital, Ghent, Belgium.
Bruno RanchinReference Center for Rare Renal Diseases, Reference Center for Rare Diseases of Calcium and Phosphate Metabolism, Pediatric Nephrology Rheumatology and Dermatology Unit, Hopital Femme Mère Enfant, Boulevard Pinel, 69677, Bron, France.
Anne SchönDepartment of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Pediatric Research Center, Hannover, Germany.
Stella Stabouli1st Department of Pediatrics, School of Medicine, Faculty of Health Sciences, Aristotle University Thessaloniki, Hippokratio Hospital, Thessaloniki, Greece.
Johan Van de WalleDepartment of Pediatric Nephrology and Rheumatology, Ghent University Hospital, Ghent, Belgium.
Enrico VidalPediatric Nephrology Unit, University-Hospital of Padova, Padua, Italy.
Dieter HaffnerDepartment of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Pediatric Research Center, Hannover, Germany.
Rukshana ShroffRenal Unit, UCL Great Ormond Street Hospital and Institute of Child Health, London, UK. rukshana.shroff@gosh.nhs.uk.
Medizinische Hochschule Hannover · DEGhent University Hospital · BEGreat Ormond Street Hospital · GBAristotle University of Thessaloniki · GRGazi University · TRHeidelberg University · DEHôpital Femme Mère Enfant · FRUniversité Claude Bernard Lyon 1 · FRUniversity of Udine · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInfants with chronic kidney disease (CKD) form a vulnerable population who are highly prone to mineral and bone disorders (MBD) including biochemical abnormalities, growth retardation, bone deformities, and fractures. We present a position paper on the diagnosis and management of CKD-MBD in infants based on available evidence and the opinion of experts from the European Society for Paediatric Nephrology (ESPN) CKD-MBD and Dialysis working groups and the Pediatric Renal Nutrition Taskforce.

methodsPICO (Patient, Intervention, Comparator, Outcomes) questions were generated, and relevant literature searches performed covering a population of infants below 2 years of age with CKD stages 2-5 or on dialysis. Clinical practice points (CPPs) were developed and leveled using the American Academy of Pediatrics grading matrix. A Delphi consensus approach was followed.

resultsWe present 34 CPPs for diagnosis and management of CKD-MBD in infants, including dietary control of calcium and phosphate, and medications to prevent and treat CKD-MBD (native and active vitamin D, calcium supplementation, phosphate binders).

conclusionAs there are few high-quality studies in this field, the strength of most statements is weak to moderate, and may need to be adapted to individual patient needs by the treating physician. Research recommendations to study key outcome measures in this unique population are suggested. A higher resolution version of the Graphical abstract is available as Supplementary information.

Indexed as

Bone DiseasesChronic Kidney Disease-Mineral and Bone DisorderNephrologyRenal Insufficiency, ChronicCalciumChildHumansInfantMineralsPhosphatesRenal DialysisCalciumMineralsPhosphatesBoneCalciumClinical practice pointsDialysisInfantsMineral and bone disordersPhosphatePTH

Identifiers

PMID36786859
PMCPMC10432337
OpenAlexW4320709275

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.