ArticleEuropean journal of nuclear medicine and molecular imaging2023
The prognostic value of CZT SPECT myocardial blood flow (MBF) quantification in patients with ischemia and no obstructive coronary artery disease (INOCA): a pilot study.
Article in European journal of nuclear medicine and molecular imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Pooled it
- The value of myocardial perfusion CZT-SPECT in the assessment of coronary microvascular dysfunction in INOCA patients: a comparative study with caIMR.The international journal of cardiovascular imaging · 2026Article
- The prognostic value of quantitative myocardial blood flow and flow reserve by dynamic CZT-SPECT for major adverse cardiovascular events.European journal of nuclear medicine and molecular imaging · 2026Article
- Value of Multi-Parameter Combined Application of CZT-SPECT and CCTA in Risk Stratification of Short-Term Myocardial Ischemic Events in Patients with Chronic Coronary Syndromes.Journal of cardiovascular development and disease · 2026Article
- The prognostic value of multiparameters derived from D-SPECT in patients with ANOCA.Annals of nuclear medicine · 2026Article
- Feasibility of Quantitative Myocardial Perfusion with CZT SPECT and SPECT/CT: Current Limitations and Recommendations for Future Improvements.Current cardiology reports · 2026Review
- Prognostic Significance of Dynamic CZT Cardiac-Dedicated SPECT-derived Myocardial Flow Reserve in Patients with Suspected or Confirmed Coronary Artery Disease and Normal Myocardial PerfusionCurrent medical imaging · 2026Article
- D-SPECT combined with deep learning predicts obstructive coronary artery disease.Frontiers in cardiovascular medicine · 2026Article
- Associations of AI-derived coronary CT angiography features with CZT-SPECT coronary flow reserve and FFR-CT.Frontiers in cardiovascular medicine · 2026Article
- Brazilian Guideline for the Evaluation and Diagnosis of Chest Pain in the Emergency Department - 2025.Arquivos brasileiros de cardiologia · 2025Article
- Diagnostic and prognostic value of myocardial flow reserve quantification with single photon emission computed tomography - a systematic review and meta-analysis.EJNMMI research · 2025Article
- Quantitative Coronary CT Angiography and Pericoronary Adipose Tissue in Acute Myocardial Infarction: Relationship with Dynamic Myocardial Perfusion SPECT.Diagnostics (Basel, Switzerland) · 2025Article
- A Novel Angiography-Derived Computational Coronary Flow Reserve to Evaluate Non-Obstructive Coronary Artery Disease.Journal of cardiovascular translational research · 2025Article
- The role of deep learning in myocardial perfusion imaging for diagnosis and prognosis: A systematic review.iScience · 2024Review
- Spherization indices measured by resting SPECT improve risk stratification in patients with ischemia with non-obstructive coronary artery disease (INOCA).EJNMMI research · 2024Article
- The D-SPECT SH reconstruction protocol: improved quantification of small left ventricle volumes.EJNMMI physics · 2024Article
- Current status and perspectives of nuclear cardiology.Annals of nuclear medicine · 2024Review
- Analysis of Myocardial Flow Reserve Using the CZT Camera. Additional Value to Perfusion and Functional Information in Identifying the Cause of Chest Discomfort.Arquivos brasileiros de cardiologia · 2024Article
- The prognostic value of CZT SPECT stress myocardial blood flow (MBF) quantification-opportunity for stress-first/stress-only protocol.European journal of nuclear medicine and molecular imaging · 2024Article
- The diagnostic role of resting myocardial blood flow in STEMI patients after revascularization.Frontiers in cardiovascular medicine · 2024Article
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Authors and funding
13 authors at 2 institutions in 3 countries.
Funding
Abstract
backgroundDespite the demonstrated adverse outcome, it is difficult to early identify the risks for patients with ischemia and no obstructive coronary artery disease (INOCA). We aimed to explore the prognostic potential of CZT SPECT in INOCA patients.
methodsThe study population consisted of a retrospective cohort of 118 INOCA patients, all of whom underwent CZT SPECT imaging and invasive coronary angiography (ICA). Dynamic data were reconstructed, and MBF was quantified using net retention model. Major adverse cardiovascular events (MACEs) were defined as cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, heart failure, late coronary revascularization, or hospitalization for unstable angina.
resultsDuring a median follow-up of 15 months (interquartile range (IQR) 11-20), 19 (16.1%) MACEs occurred; both stress myocardial blood flow (sMBF) ([Formula: see text]) and coronary flow reserve (CFR) ([Formula: see text]) were significantly lower in the MACE group. Optimal thresholds of sMBF<3.16 and CFR<2.52 were extracted from the ROC curves, and both impaired sMBF (HR: 15.08; 95% CI 2.95-77.07; [Formula: see text]) and CFR (HR: 6.51; 95% CI 1.43-29.65; [Formula: see text]) were identified as prognostic factors for MACEs. Only sMBF<3.16 (HR: 11.20; 95% CI 2.04-61.41; [Formula: see text]) remained a robust predictor when sMBF and CFR were integrated considered. Compared with CFR, sMBF provides better prognostic model discrimination and reclassification ability (C-index improvement = 0.06, [Formula: see text]; net reclassification improvement (NRI) = 0.19; integrated discrimination improvement (IDI) = 0.10).
conclusionThe preliminary results demonstrated that quantitative analysis on CZT SPECT provides prognostic value for INOCA patients, which may allow the stratification for early prevention and intervention.
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