Evidence map›Paper›PMID 36786609›Full record

ArticleAntimicrobial agents and chemotherapy2023

Positron Emission Tomography-Based Pharmacokinetic Analysis To Assess Renal Transporter-Mediated Drug-Drug Interactions of Antimicrobial Drugs.

Irene Hernández-Lozano, Severin Mairinger, Thomas Filip, Mathilde Löbsch, Johann Stanek, Claudia Kuntner, Martin Bauer, Markus Zeitlinger, Marcus Hacker, Thomas H Helbich and 2 more

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Effect of probenecid on the whole-body disposition of 6-bromo-7-[European journal of nuclear medicine and molecular imaging · 2025
    Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Irene Hernández-LozanoDepartment of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
Severin MairingerDepartment of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
Thomas FilipCore Facility Laboratory Animal Breeding and Husbandry, Medical University of Vienna, Vienna, Austria.
Mathilde LöbschCore Facility Laboratory Animal Breeding and Husbandry, Medical University of Vienna, Vienna, Austria.
Johann StanekDepartment of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.
Claudia KuntnerDepartment of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.
Martin BauerDepartment of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
Markus ZeitlingerDepartment of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-1873-3953
Marcus HackerDepartment of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.
Thomas H HelbichDepartment of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.
Thomas WanekDepartment of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.
Oliver LangerDepartment of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-4048-5781
Medical University of Vienna · AT

Funding

EPA EP-C-17-009
6 · The paper itself

Abstract

Transporter-mediated drug-drug interactions (DDIs) are of concern in antimicrobial drug development, as they can have serious safety consequences. We used positron emission tomography (PET) imaging-based pharmacokinetic (PK) analysis to assess the effect of different drugs, which may cause transporter-mediated DDIs, on the tissue distribution and excretion of [

Indexed as

Anti-Infective AgentsProbenecidAnimalsCimetidineCiprofloxacinDrug InteractionsHumansKidneyMembrane Transport ProteinsMicePositron-Emission TomographyAnti-Infective AgentsCimetidineCiprofloxacinMembrane Transport ProteinsProbenecidantimicrobial drug dispositiondrug-drug interactionmembrane transporterspositron emission tomographyrenal clearance

Identifiers

PMID36786609
PMCPMC10019293
OpenAlexW4320709543

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.