Evidence map›Paper›PMID 36786597›Full record

ArticlemBio2023

Genetic Ablation of a Female-Specific Apetala 2 Transcription Factor Blocks Oocyst Shedding in Cryptosporidium parvum.

Jayesh Tandel, Katelyn A Walzer, Jessica H Byerly, Brittain Pinkston, Daniel P Beiting, Boris Striepen

Open access · goldAbstract read
In one paragraph

Article in mBio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
12.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
  2. Genetic Manipulation of Cryptosporidium parvum.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  3. Review
  4. Molecular biology of the cell · 2025
    Article
  5. Article
  6. Article
  7. Organoid-basedMicrobiology spectrum · 2025
    Article
  8. Article
  9. Article
  10. Deciphering Transcription inbioRxiv : the preprint server for biology · 2025
    Article
  11. Gene regulation inCurrent research in parasitology & vector-borne diseases · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Genetic crosses within and between species ofProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  19. Current tropical medicine reports · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jayesh TandelDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Katelyn A WalzerDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-1179-9164
Jessica H ByerlyDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Brittain PinkstonCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA.
Daniel P BeitingDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-2865-4589
Boris StriepenDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-7426-432X
University of Georgia · USUniversity of Pennsylvania · US

Funding

Genetic Analysis of CryptosporidiumR01AI112427 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI STRIEPEN, BORIS · 2014 to 2023
$4.2M
Sexual Development of CryptosporidiumR01AI127798 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI STRIEPEN, BORIS · 2017 to 2025
$4.1M
Genetic Analysis of CryptosporidiumR37AI112427 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI BORIS STRIEPEN · 2024 to 2026
$1.5M
Elucidating the roles of transcriptional regulators during the Cryptosporidium life cycleF32AI154666 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI WALZER, KATELYN ANN · 2020 to 2022
$206k
NIAID NIH HHS F32 AI154666NIAID NIH HHS R01 AI112427NIAID NIH HHS R01 AI127798NIAID NIH HHS R37 AI112427
6 · The paper itself

Abstract

The apicomplexan parasite

Indexed as

CryptosporidiosisCryptosporidiumCryptosporidium parvumAnimalsDiarrheaFecesFemaleLife Cycle StagesMaleOocystsTranscription FactorsTranscription FactorsAP2apicomplexan parasitesCryptosporidiumintestinesextranscription

Identifiers

PMID36786597
PMCPMC10233709
OpenAlexW4320709516

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.