Evidence map›Paper›PMID 36786506›Full record

ArticleAnnals of medicine2023

Outcome of transcatheter atrial septal defect closure in a nationwide cohort.

V Muroke, M Jalanko, J Haukka, J Hartikainen, A Tahvanainen, H Ukkonen, K Ylitalo, J Pihkala, J Sinisalo

Open access · goldAbstract read
In one paragraph

Article in Annals of medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Outcomes Analysis of Transcatheter Closure of Atrial Septal Defects.Journal of the American Heart Association · 2025
    Article
  7. Review
  8. Bimodal Distribution of Atrial Arrhythmias After Transcatheter Atrial Septal Defect Closure.Journal of the Society for Cardiovascular Angiography & Interventions · 2025
    Article
  9. The Evaluation of P-Wave Parameters in Patients With Percutaneous Closure of Atrial Septal Defect.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2025
    Article
  10. Secundum atrial septal defect closure in adults in the UK.European heart journal. Quality of care & clinical outcomes · 2025
    Observational
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

V MurokeDepartment of Cardiology, Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0003-0972-3873
M JalankoDepartment of Cardiology, Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0001-5409-3300
J HaukkaDepartment of Public Health, University of Helsinki, Helsinki, Finland.ORCID 0000-0003-1450-6208
J HartikainenDepartment of Cardiology, Kuopio University Hospital, Kuopio, Finland.ORCID 0000-0003-0847-107X
A TahvanainenDepartment of Cardiology, Tampere University Hospital, Tampere, Finland.
H UkkonenHeart Centre, Turku University Hospital, Turku, Finland.ORCID 0000-0002-2931-3073
K YlitaloDepartment of Cardiology, Oulu University Hospital, Oulu, Finland.
J PihkalaDepartment of Cardiology, New Children's Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.ORCID 0000-0003-0587-5765
J SinisaloDepartment of Cardiology, Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0002-0169-5137
Helsinki University Hospital · FIUniversity of Helsinki · FIKuopio University Hospital · FIOulu University Hospital · FITampere University Hospital · FITurku University Hospital · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTranscatheter (TC) atrial septal defect (ASD) closure has been the mainstay of therapy for secundum-type ASDs for over 20 years.

aimsThis nationwide cohort evaluated the long-term outcome of transcatheter-closed ASDs.

methodsThe study enrolled every transcatheter ASD closure performed in Finland from 1999 to 2019. Five age, sex, and municipality-matched controls per ASD patient were gathered from the general population. The median follow-up period was 5.9 years (range 0-20.8). We used the hospital discharge register to gather all hospital visits and diagnoses. Closure complications and echocardiographic changes were collected from the electronic health records.

resultsTranscatheter ASD closure was performed in 1000 patients (68.5% females) during the study period. The median (range) age at the time of the procedure was 37.9 (1.8-87.5) years. ASD patients had an increased risk for new-onset atrial fibrillation (RR 2.45, 95% CI: 1.84-3.25), migraine (RR 3.61, 95% CI: 2.54-5.14), ischemic heart disease (RR 1.73, 95% CI: 1.23-2.45), ventricular fibrillation/tachycardia (RR 3.54 (95% CI: 1.48-8.43) and AV conduction disorder (RR 3.60, 95% CI: 1.94-6.70) compared to the control cohort. Stroke risk was not increased (RR 1.36, 95% CI: 0.91-2.03). Adverse events occurred in 6.3% (

conclusionAfter TC closure of ASD, patients had a higher risk of new-onset atrial fibrillation and migraine

Indexed as

Atrial FibrillationHeart Septal Defects, AtrialAdultAgedAged, 80 and overCardiac CatheterizationFemaleHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeVentricular Fibrillationatrial fibrillationAtrial septal defectcomplicationcongenital heart diseasemigrainestroketranscatheter closure

Identifiers

PMID36786506
PMCPMC9930864
OpenAlexW4320709274

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.