Evidence map›Paper›PMID 36786505›Full record

ArticleClinical transplantation2023

Critical interactions between race and the highly granular area deprivation index in liver transplant evaluation.

Alexandra T Strauss, Eric Moughames, John W Jackson, Daniel Malinsky, Dorry L Segev, James P Hamilton, Jacqueline Garonzik-Wang, Ahmet Gurakar, Andrew Cameron, Lorraine Dean and 3 more

Abstract read
In one paragraph

Article in Clinical transplantation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Interrogating the Mechanistic Link between Neighborhood Deprivation and Colorectal Cancer Risk through Transcriptomic Analysis of Normal Colorectal Biopsies.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026
    Article
  4. Article
  5. Article
  6. Role of social determinants and outcomes of patients with alcohol-associated liver disease referred for early liver transplantation: A multicenter analysis.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026
    Article
  7. Article
  8. Observational
  9. Association between Area Deprivation Index, Kidney Transplant Waitlisting, and Reasons for Denial.Clinical journal of the American Society of Nephrology : CJASN · 2026
    Article
  10. Article
  11. Access to early liver transplantation is adversely impacted by social determinants of health: A retrospective cohort study.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2025
    Article
  12. Article
  13. Racial and ethnic disparities in liver transplant access vary within and across transplant referral regions.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2025
    Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Where you live matters: Area deprivation predicts poor survival and liver transplant waitlisting.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024
    Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Alexandra T StraussDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-6313-7221
Eric MoughamesDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
John W JacksonDepartment of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland, USA.
Daniel MalinskyDepartment of Biostatistics, Columbia University Mailman School of Public Health, New York, New York, USA.
Dorry L SegevDepartment of Surgery, New York University, Grossman School of Medicine, New York, New York, USA.
James P HamiltonDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Jacqueline Garonzik-WangDepartment of Surgery, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin, USA.
Ahmet GurakarDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-2221-9148
Andrew CameronDepartment of Surgery, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA.
Lorraine DeanDepartment of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland, USA.
Eili KleinDepartment of Emergency Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA.
Scott LevinDepartment of Emergency Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA.
Tanjala S PurnellDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-8661-7911

Funding

Patient Oriented Research in Solid Organ TransplantationK24AI144954 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SEGEV, DORRY L. · 2020 to 2024
$956k
Improving the liver transplant evaluation process: a data science-focused and team-based approachK08DK133638 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI Alexandra Teresa Strauss · 2022 to 2026
$864k
Systems Science for Translational Health Disparities ResearchK01HL145320 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI JACKSON, JOHN WILLIAM · 2019 to 2023
$832k
Patient-Centered Strategies to Reduce Disparities in Access to Kidney TransplantationK01HS024600 · AHRQ · JOHNS HOPKINS UNIVERSITY · PI PURNELL, TANJALA · 2016 to 2020
$786k
AHRQ HHS K01 HS024600NHLBI NIH HHS K01 HL145320NIAID NIH HHS K24 AI144954NIDDK NIH HHS K08 DK133638
6 · The paper itself

Abstract

Neighborhood socioeconomic deprivation may have important implications on disparities in liver transplant (LT) evaluation. In this retrospective cohort study, we constructed a novel dataset by linking individual patient-level data with the highly granular Area Deprivation Index (ADI), which is advantageous over other neighborhood measures due to: specificity of Census Block-Group (versus Census Tract, Zip code), scoring, and robust variables. Our cohort included 1377 adults referred to our center for LT evaluation 8/1/2016-12/31/2019. Using modified Poisson regression, we tested for effect measure modification of the association between neighborhood socioeconomic status (nSES) and LT evaluation outcomes (listing, initiating evaluation, and death) by race and ethnicity. Compared to patients with high nSES, those with low nSES were at higher risk of not being listed (aRR = 1.14; 95%CI 1.05-1.22; p < .001), of not initiating evaluation post-referral (aRR = 1.20; 95%CI 1.01-1.42; p = .03) and of dying without initiating evaluation (aRR = 1.55; 95%CI 1.09-2.2; p = .01). While White patients with low nSES had similar rates of listing compared to White patients with high nSES (aRR = 1.06; 95%CI .96-1.17; p = .25), Underrepresented patients from neighborhoods with low nSES incurred 31% higher risk of not being listed compared to Underrepresented patients from neighborhoods with high nSES (aRR = 1.31; 95%CI 1.12-1.5; p < .001). Interventions addressing neighborhood deprivation may not only benefit patients with low nSES but may address racial and ethnic inequities.

Indexed as

Liver TransplantationAdultEthnicityHumansOutcome Assessment, Health CareRetrospective StudiesSocial Classliver transplantationracial groupsresidence characteristics

Identifiers

PMID36786505
PMCPMC10175104

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.