ArticleIUCrJ2023
Bone mineral properties and 3D orientation of human lamellar bone around cement lines and the Haversian system.
Article in IUCrJ, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
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- Dynamic sampling for SAXSTT: towards real-time measurement adaptation.Journal of synchrotron radiation · 2026Article
- Fast Small-Angle X-Ray Scattering Tensor Tomography: An Outlook into Future Applications in Life Sciences.Small methods · 2026Article
- Computational corrections for anisotropic absorption in tensor tomography.Journal of synchrotron radiation · 2025Article
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- Nanocrystal Compressive Residual Stresses: A Strategy to Strengthen the Bony Spines of Osteocytic and Anosteocytic Fish.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Texture tomography with high angular resolution utilizing sparsity.Journal of applied crystallography · 2025Article
- A micro-beamstop with transmission detection by fluorescence for scanning-beam synchrotron scattering beamlines.Journal of applied crystallography · 2024Article
- Investigating the missing-wedge problem in small-angle X-ray scattering tensor tomography across real and reciprocal space.Journal of synchrotron radiation · 2024Article
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- Crossing length scales: X-ray approaches to studying the structure of biological materials.IUCrJ · 2024Review
- Bone hierarchical organization through the lens of materials science: Present opportunities and future challenges.Bone reports · 2024Review
- X-ray tensor tomography for small-grained polycrystals with strong texture.Journal of applied crystallography · 2024Article
- A step towards 6D WAXD tensor tomography.IUCrJ · 2024Article
- Characterization of the mechanical properties of the mouse Achilles tendon enthesis by microindentation. Effects of unloading and subsequent reloading.Bone reports · 2024Article
- Molecularly Imprinted Polymers: Shaping the Future of Early-Stage Bone Loss Detection-A Review.ACS omega · 2024Review
- Recent developments in X-ray diffraction/scattering computed tomography for materials science.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2023Review
- Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Bone is a complex, biological tissue made up primarily of collagen fibrils and biomineral nanoparticles. The importance of hierarchical organization in bone was realized early on, but the actual interplay between structural features and the properties on the nanostructural and crystallographic level is still a matter of intense discussion. Bone is the only mineralized tissue that can be remodeled and, at the start of the formation of new bone during this process, a structure called a cement line is formed on which regular bone grows. Here, the orientational relationship of nanostructural and crystallographic constituents as well as the structural properties of both nanostructural and crystallographic constituents around cement lines and the Haversian system in human lamellar bone are investigated. A combination of small- and wide-angle X-ray scattering tensor tomography is employed together with diffraction tomography and synchrotron computed tomography to generate a multi-modal image of the sample. This work shows that the mineral properties vary as a function of the distance to the Haversian canal and, importantly, shows that the cement line has differing mineral properties from the surrounding lamellar bone, in particular with respect to crystallite size and degree of orientation. Cement lines make up a significant portion of the bone matrix despite their small size, hence the reported findings on an altered mineral structure, together with the spatial modulation around the Haversian canal, have implications for the formation and mechanics of bone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.