Evidence map›Paper›PMID 36786424›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2023

Cognition in patients with neuromyelitis optica spectrum disorders: A prospective multicentre study of 217 patients (CogniNMO-Study).

Martin W Hümmert, Carlotta Stern, Friedemann Paul, Ankelien Duchow, Judith Bellmann-Strobl, Ilya Ayzenberg, Carolin Schwake, Ingo Kleiter, Kerstin Hellwig, Sven Jarius and 22 more

Open access · hybridAbstract readMulticenter Study
In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Observational
  8. Review
  9. Article
  10. Correlation of GABABrain and behavior · 2024
    Article
  11. Cognitive function and brain magnetic resonance imaging profiles in neuromyelitis optica spectrum disorder and multiple sclerosis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2024
    Article
  12. Review
  13. Exploring subcortical pathology and processing speed in neuromyelitis optica spectrum disorder with myelin water imaging.Journal of neuroimaging : official journal of the American Society of Neuroimaging
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 18 institutions in 2 countries.

Martin W HümmertDepartment of Neurology, Hannover Medical School, Hannover, Germany.ORCID 0000-0002-5928-2343
Carlotta SternDepartment of Neurology, Hannover Medical School, Hannover, Germany.ORCID 0000-0002-6150-7564
Friedemann PaulNeuroCure Clinical Research Center, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, and Max Delbrück Center for Molecular Medicine, Berlin, Germany/Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany/ Department of Neurology, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Ankelien DuchowNeuroCure Clinical Research Center, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, and Max Delbrück Center for Molecular Medicine, Berlin, Germany/Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Judith Bellmann-StroblNeuroCure Clinical Research Center, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, and Max Delbrück Center for Molecular Medicine, Berlin, Germany/Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Ilya AyzenbergDepartment of Neurology, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany.
Carolin SchwakeDepartment of Neurology, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany.
Ingo KleiterDepartment of Neurology, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany/Marianne-Strauß-Klinik, Behandlungszentrum Kempfenhausen für Multiple Sklerose Kranke, Berg, Germany.
Kerstin HellwigDepartment of Neurology, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany.ORCID 0000-0003-4467-9011
Sven JariusMolecular Neuroimmunology Group, Department of Neurology, University of Heidelberg, Heidelberg, Germany.
Brigitte WildemannMolecular Neuroimmunology Group, Department of Neurology, University of Heidelberg, Heidelberg, Germany.
Makbule SenelDepartment of Neurology, University of Ulm, Ulm, Germany.
Achim BertheleDepartment of Neurology, School of Medicine, Technical University Munich, Klinikum rechts der Isar, Munich, Germany.
Katrin GiglhuberDepartment of Neurology, School of Medicine, Technical University Munich, Klinikum rechts der Isar, Munich, Germany.
Felix LuessiDepartment of Neurology, University Medical Center, Johannes Gutenberg University of Mainz, Mainz, Germany.
Matthias GrotheDepartment of Neurology, University Medicine of Greifswald, Greifswald, Germany.
Luisa KlotzDepartment of Neurology, University of Münster, Münster, Germany.
Rasmus SchülkeDepartment of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany.
Stefan GingeleDepartment of Neurology, Hannover Medical School, Hannover, Germany.
Jürgen H FaissDepartment of Neurology, Asklepios Expert Clinic Teupitz, Teupitz, Germany.
Annette WalterDepartment of Neurology, Herford Hospital, Herford, Germany.
Clemens WarnkeDepartment of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0002-3510-9255
Florian Then BerghDepartment of Neurology, University of Leipzig, Leipzig, Germany.
Orhan AktasDepartment of Neurology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Marius RingelsteinDepartment of Neurology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany/Department of Neurology, Center for Neurology and Neuropsychiatry, LVR-Klinikum, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Jan-Patrick StellmannDepartment of Neurology and Institute of Neuroimmunology and Multiple Sclerosis (INIMS), University Medical Center Hamburg-Eppendorf, Hamburg, Germany/Aix-Marseille Univ, CNRS, CRMBM, UMR 7339, Marseille, France/APHM, Hopital de la Timone, CEMEREM, Marseille, France.
Vivien HäußlerDepartment of Neurology and Institute of Neuroimmunology and Multiple Sclerosis (INIMS), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-7787-7391
Joachim HavlaInstitute of Clinical Neuroimmunology, LMU Hospital, Ludwig-Maximilians-Universität München, Munich, Germany/Data Integration for Future Medicine Consortium, LMU Hospital, Ludwig-Maximilians Universität München, Munich, Germany.ORCID 0000-0002-4386-1340
Hannah PellkoferInstitute of Clinical Neuroimmunology, LMU Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.
Tania KümpfelInstitute of Clinical Neuroimmunology, LMU Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.
Bruno KoppDepartment of Neurology, Hannover Medical School, Hannover, Germany.
Corinna TrebstDepartment of Neurology, Hannover Medical School, Hannover, Germany.
Medizinische Hochschule Hannover · DESt. Josef-Hospital · DELudwig-Maximilians-Universität München · DEHeidelberg University · DEHeinrich Heine University Düsseldorf · DEMax Delbrück Center · DETUM Klinikum · DECentre National de la Recherche Scientifique · FRHerford Hospital · DEHumboldt-Universität zu Berlin · DEJohannes Gutenberg University Mainz · DEKlinikum Görlitz · DELeipzig University · DEUniversität Hamburg · DEUniversitätsmedizin Greifswald · DEUniversität Ulm · DEUniversity of Cologne · DEUniversity of Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is limited and inconsistent information on the prevalence of cognitive impairment in neuromyelitis optica spectrum disorders (NMOSD).

objectiveTo assess cognitive performance and changes over time in NMOSD.

methodsThis study included data from 217 aquaporin-4-IgG-seropositive (80%) and double-seronegative NMOSD patients. Cognitive functions measured by Symbol Digit Modalities Test (SDMT), Paced Auditory Serial-Addition Task (PASAT), and/or Multiple Sclerosis Inventory Cognition (MuSIC) were standardized against normative data (

resultsNMOSD patients were impaired in SDMT (

conclusionsA subset of NMOSD patients shows impairment in visual processing speed and in semantic fluency regardless of serostatus, without noticeable changes during a 2-year observation period. Neuropsychological measurements should be adapted to physical and visual disabilities.

Indexed as

Multiple SclerosisNeuromyelitis OpticaAquaporin 4AutoantibodiesCognitionHumansImmunoglobulin GProspective StudiesAquaporin 4AutoantibodiesImmunoglobulin Gcognitioncognitive neuropsychologyneuroimmunologyNeuromyelitis optica spectrum disorders

Identifiers

PMID36786424
PMCPMC10278388
OpenAlexW4320709119

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.