Evidence map›Paper›PMID 36786285›Full record

ArticleIET nanobiotechnology2023

Anionic liposomes prepared without organic solvents for effective siRNA delivery.

Xiu Han, Yan Lu, Zhaoluo Xu, Yanan Chu, Xueping Ma, Haiping Wu, Bingjie Zou, Guohua Zhou

Open access · goldAbstract read
In one paragraph

Article in IET nanobiotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Xiu HanDepartment of Clinical Pharmacy, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Yan LuDepartment of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China.
Zhaoluo XuDepartment of Clinical Pharmacy, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Yanan ChuDepartment of Clinical Pharmacy, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Xueping MaDepartment of Clinical Pharmacy, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Haiping WuDepartment of Clinical Pharmacy, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Bingjie ZouKey Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, School of Pharmacy, China Pharmaceutical University, Nanjing, China.
Guohua ZhouDepartment of Clinical Pharmacy, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, China.ORCID https://orcid.org/0000-0001-6675-4452
Nanjing General Hospital of Nanjing Military Command · CNChina Pharmaceutical University · CNNanjing Children's Hospital · CN

Funding

Fundamental Research Funds for the Central Universities 2022300326National Natural Science Foundation of China 61871403
6 · The paper itself

Abstract

Currently, organic solvents are necessary for the preparation of anionic liposomes for siRNA delivery. The removal of organic solvent is time-consuming and the residual organic solvent is not only a hidden danger, but also affects the stability of anionic liposomes. Glycerol, which is physiologically compatible and does not need to be removed, is used to promote the dispersion of lipids and the formation of anionic liposomes. Additionally, the preparation process is simple and not time-consuming. The results showed that anionic liposomes, which were typically spherical with a particle size of 188.9 nm were successfully prepared with glycerol. And with the help of Ca

Indexed as

GlycerolLiposomesParticle SizeRNA, Small InterferingSolventsGlycerolLiposomesRNA, Small InterferingSolventsanionic liposomeorganic solventsiRNA

Identifiers

PMID36786285
PMCPMC10190622
OpenAlexW4320710225

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.