ArticleMedical physics2023
Fraction optimization for hybrid proton-photon treatment planning.
Article in Medical physics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Optimizing allocation of limited proton fractions via NTCP-optimized combined proton-photon radiotherapy.Physical and engineering sciences in medicine · 2026Article
- Photon minibeam-based LATTICE radiotherapy for small and medium-sized tumors: A dosimetric planning study.Medical physics · 2026Article
- Collimator position optimization for proton minibeam radiation therapy.Scientific reports · 2026Article
- Collimator position optimization for proton minibeam radiation therapy.Research square · 2026Article
- Dose optimization with fully flexible vertex positioning for LATTICE radiotherapy.Medical physics · 2026Article
- Article
- Optimizing normal tissue sparing via spatiotemporal optimization under equivalent tumor-radical efficacy.ArXiv · 2025Article
- New energy layer reduction method for rapid intensity-modulated proton therapy (IMPT) using a ridge filter.Medical physics · 2025Article
- A fully flexible joint lattice position and dose optimization method for LATTICE therapy.ArXiv · 2025Article
- Article
- Direct minimization of normal-tissue toxicity via an NTCP-based IMPT planning method.Medical physics · 2025Article
- Dosimetric optimization for dynamic mixed beam arc therapy (DYMBARC).Medical physics · 2025Article
- Proton ARC based LATTICE radiation therapy: feasibility study, energy layer optimization and LET optimization.Physics in medicine and biology · 2024Article
- TEAM: Triangular-mEsh Adaptive and Multiscale proton spot generation method.Medical physics · 2024Article
- Simultaneous dose and dose rate optimization via dose modifying factor modeling for FLASH effective dose.Medical physics · 2024Article
- Biological optimization for hybrid proton-photon radiotherapy.Physics in medicine and biology · 2024Article
- Single high-energy arc proton therapy with Bragg peak boost (SHARP).Journal of medical radiation sciences · 2024Article
- Lattice position optimization for LATTICE therapy.Medical physics · 2023Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundHybrid proton-photon radiotherapy (RT) can provide better plan quality than proton or photon only RT, in terms of robustness of target coverage and sparing of organs-at-risk (OAR). PURPOSE: This work develops a hybrid treatment planning method that can optimize the number of proton and photon fractions as well as proton and photon plan variables, so that the hybrid plans can be clinically delivered day-to-day using either proton or photon machine.
methodsIn the new hybrid treatment planning method, the total dose distribution (sum of proton dose and photon dose) is optimized for robust target coverage and optimal OAR sparing, by jointly optimizing proton spots and photon fluences, while the target dose uniformity is also enforced individually on both proton dose and photon dose, so that the hybrid plans can be separately and robustly delivered on proton or photon machine. To ensure the target dose uniformity for proton and photon plans, the number of proton and photon fractions is explicitly modeled and optimized, so that the target dose for proton and photon dose components is constrained to be a constant fraction of the total prescription dose while the plan quality based on total dose is optimized. The feasibility of hybrid planning using the proposed method is validated with representative clinical cases including abdomen, lung, head-and-neck (HN), and brain.
resultsFor all cases, hybrid plans provided better overall plan quality and OAR sparing than proton-only or photon-only plans, better target dose uniformity and robustness than proton-only plans, quantified by treatment planning objectives and dosimetric parameters. Moreover, for HN and brain cases, hybrid plans also had better target coverage than photon-only plans.
conclusionsWe have developed a new hybrid treatment planning method that optimizes number of proton and photon fractions as well as proton spots and photon fluences, for generating hybrid plans that can be separately and robustly delivered on proton or photon machines. Preliminary results have demonstrated that hybrid plans generated by the new method have better plan quality than proton-only or photon-only plans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.