ArticleACS measurement science au2022
Simultaneous Detection of Hypochlorite and Singlet Oxygen by a Thiocoumarin-Based Ratiometric Fluorescent Probe.
Article in ACS measurement science au, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 21 citations in OpenAlex.
- Recent advances in small-molecule fluorescent probes for simultaneous dual detection of HClO/ClOChemical science · 2026Review
- A Bifunctional Fluorescence Probe for the Detection of Hypochlorous Acid and Viscosity in Living Cells and Zebrafish.Molecules (Basel, Switzerland) · 2025Article
- Highly efficient CaOrganic & biomolecular chemistry · 2024Article
- Thioxobimanes.The Journal of organic chemistry · 2023Article
- Recent Development of Lysosome-Targeted Organic Fluorescent Probes for Reactive Oxygen Species.Molecules (Basel, Switzerland) · 2023Review
- A ratiometric near-infrared fluorescent probe for the detection and monitoring of hypochlorous acid in rheumatoid arthritis model and real water samples.Smart molecules : open access · 2023Article
- Thiocoumarins: From the Synthesis to the Biological Applications.Molecules (Basel, Switzerland) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of fluorescent probes derived from thiocarbonyl compounds for reactive oxygen species has been actively pursued in recent years. However, a better understanding of the optical response behaviors of thiocarbonyl compounds toward reactive oxygen species remains a challenge. Along with this, further studies to overcome the limitation of a single emission channel and aggregation-caused quenching features of thiocarbonyl-based fluorescent probes are highly desirable. Due to the important role of hypochlorite and singlet oxygen in biological processes and their common coexistence in living systems with frequent intertransformations, the design of a fluorescent probe that can recognize both hypochlorite and singlet oxygen is of great interest. Herein, a thiocarbonyl-based ratiometric fluorescent probe (Fcoum-S) for simultaneous detection of hypochlorite and singlet oxygen in aqueous solution and living cells was designed and synthesized. Upon the addition of hypochlorite in Fcoum-S solution (phosphate-buffered saline, 10 mM, pH 7.4, 10% acetonitrile), a ratiometric fluorescence response was observed via a specific hypochlorite-promoted desulfurization reaction with a good linear relationship between the ratio of fluorescence intensities at 526 and 602 nm (
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.