Evidence map›Paper›PMID 36785842›Full record

ArticleEnvironmental advances2023

Identifying environmental risk factors for post-acute sequelae of SARS-CoV-2 infection: An EHR-based cohort study from the recover program.

Yongkang Zhang, Hui Hu, Vasilios Fokaidis, Colby Lewis V, Jie Xu, Chengxi Zang, Zhenxing Xu, Fei Wang, Michael Koropsak, Jiang Bian and 7 more

Abstract read
In one paragraph

Article in Environmental advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Ambient Air Pollution and COVID-19 in California.Research report (Health Effects Institute) · 2026
    Article
  3. Observational
  4. Article
  5. Article
  6. Article
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  8. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Yongkang ZhangDepartment of Population Health Sciences, Weill Cornell Medicine, New York, NY, United States.
Hui HuChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.
Vasilios FokaidisDepartment of Population Health Sciences, Weill Cornell Medicine, New York, NY, United States.
Colby Lewis VDepartment of Population Health Sciences, Weill Cornell Medicine, New York, NY, United States.
Jie XuDepartment of Health Outcomes Biomedical Informatics, University of Florida, Gainesville, FL, United States.
Chengxi ZangDepartment of Population Health Sciences, Weill Cornell Medicine, New York, NY, United States.
Zhenxing XuDepartment of Population Health Sciences, Weill Cornell Medicine, New York, NY, United States.
Fei WangDepartment of Population Health Sciences, Weill Cornell Medicine, New York, NY, United States.
Michael KoropsakDepartment of Population Health Sciences, Weill Cornell Medicine, New York, NY, United States.
Jiang BianDepartment of Health Outcomes Biomedical Informatics, University of Florida, Gainesville, FL, United States.
Jaclyn HallDepartment of Health Outcomes Biomedical Informatics, University of Florida, Gainesville, FL, United States.
Russell L RothmanInstitute of Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN, United States.
Elizabeth A ShenkmanDepartment of Health Outcomes Biomedical Informatics, University of Florida, Gainesville, FL, United States.
Wei-Qi WeiDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, United States.
Mark G WeinerDepartment of Population Health Sciences, Weill Cornell Medicine, New York, NY, United States.
Thomas W CartonLouisiana Public Health Institute, New Orleans, LA, United States.
Rainu KaushalDepartment of Population Health Sciences, Weill Cornell Medicine, New York, NY, United States.

Funding

OTA-21-015A Post-Acute Sequelae of SARS-CoV-2 Infection Initiative: NYU Langone Health Clinical Science Core, Data Resource Core, and PASC Biorepository CoreOT2HL161847 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GROSS, RACHEL SHARON, HORWITZ, LEORA · 2021 to 2025
$651.0M
NHLBI NIH HHS OT2 HL161847
6 · The paper itself

Abstract

Post-acute sequelae of SARS-CoV-2 infection (PASC) affects a wide range of organ systems among a large proportion of patients with SARS-CoV-2 infection. Although studies have identified a broad set of patient-level risk factors for PASC, little is known about the association between "exposome"-the totality of environmental exposures and the risk of PASC. Using electronic health data of patients with COVID-19 from two large clinical research networks in New York City and Florida, we identified environmental risk factors for 23 PASC symptoms and conditions from nearly 200 exposome factors. The three domains of exposome include natural environment, built environment, and social environment. We conducted a two-phase environment-wide association study. In Phase 1, we ran a mixed effects logistic regression with 5-digit ZIP Code tabulation area (ZCTA5) random intercepts for each PASC outcome and each exposome factor, adjusting for a comprehensive set of patient-level confounders. In Phase 2, we ran a mixed effects logistic regression for each PASC outcome including all significant (false positive discovery adjusted p-value < 0.05) exposome characteristics identified from Phase I and adjusting for confounders. We identified air toxicants (e.g., methyl methacrylate), particulate matter (PM

Indexed as

Air pollutionBuilt environmentExposomeLong-COVIDNeighborhood deprivationSARS-CoV-2 infection

Identifiers

PMID36785842
PMCPMC9907788

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.