ArticleResearch and practice in thrombosis and haemostasis2023
Heterophilic antibodies leading to falsely positive D-dimer concentration in an adolescent.
Article in Research and practice in thrombosis and haemostasis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Application and concentration selection of dithiothreitol for correcting false elevation of D-dimer.Practical laboratory medicine · 2025Article
- D-dimer assay interference detected by the discrepancy in D-dimer concentrations at different dilutions: a case report.Biochemia medica · 2024Article
- Interfering antibodies may contribute to elevated D-dimer: a case report.Journal of medical case reports · 2024Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: We present the case of a 15-year-old adolescent with suspected pulmonary embolism and repeatedly elevated D-dimer levels. Key Clinical Question: We aim to determine the cause for elevated D-dimer levels in a patient without venous thromboembolism. Clinical Approach: When the D-dimer measurement was repeated with different assays, D-dimer levels were within the normal reference interval. Dilution series with assay diluent or low-affinity antibody blocking reagents either did not or only partially decreased the D-dimer value using the original reagent kit. Conclusion: Analyses suggested the presence of interfering heterophilic antibodies in patient plasma, a known phenomenon with immunoturbidimetric D-dimer assays, which is rarely described. Prior to drawing this conclusion, the patient underwent extensive diagnostic testing, which led to uncertainty and discomfort for the health care providers, the patient, and their family.
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Registered trials
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