Evidence map›Paper›PMID 36785744›Full record

ArticleACS measurement science au2021

Electrochemical Immunosensing of Interleukin-6 in Human Cerebrospinal Fluid and Human Serum as an Early Biomarker for Traumatic Brain Injury.

Christiana Oh, Bumjun Park, Chunyan Li, Charles Maldarelli, Jennifer L Schaefer, Timir Datta-Chaudhuri, Paul W Bohn

Open access · goldAbstract read
In one paragraph

Article in ACS measurement science au, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 45 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Christiana OhDepartment of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, Indiana 46556, United States.ORCID https://orcid.org/0000-0002-6018-920X
Bumjun ParkDepartment of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, Indiana 46556, United States.ORCID https://orcid.org/0000-0002-3779-1315
Chunyan LiInstitute for Bioelectronic Medicine, Feinstein Institutes for Medical Research, Manhasset, New York 11030, United States.
Charles MaldarelliThe Benjamin Levich Institute for Physicochemical Hydrodynamics and Department of Chemical Engineering, The City College of New York, New York, New York 10031, United States.ORCID https://orcid.org/0000-0001-7427-2349
Jennifer L SchaeferDepartment of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, Indiana 46556, United States.ORCID https://orcid.org/0000-0003-4293-6328
Timir Datta-ChaudhuriInstitute for Bioelectronic Medicine, Feinstein Institutes for Medical Research, Manhasset, New York 11030, United States.ORCID https://orcid.org/0000-0001-7377-1939
Paul W BohnDepartment of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, Indiana 46556, United States.ORCID https://orcid.org/0000-0001-9052-0349
University of Notre Dame · USFeinstein Institute for Medical Research · USCity College of New York · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this work, we develop a label-free electrochemical immunosensor for the detection of interleukin-6 (IL-6) in human cerebrospinal fluid (CSF) and serum for diagnostic and therapeutic monitoring. The IL-6 immunosensor is fabricated from gold interdigitated electrode arrays (IDEAs) that are modified with IL-6 antibodies for direct antigen recognition and capture. A rigorous surface analysis of the sensor architecture was conducted to ensure high structural fidelity and performance. Electrochemical characterization was conducted by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS), and sensing was performed using differential pulse voltammetry (DPV). The DPV peak current was used to quantify IL-6 in buffer, CSF, and serum in the range 1 pg mL

Identifiers

PMID36785744
PMCPMC9838612
OpenAlexW3191190184

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.