Evidence map›Paper›PMID 36785735›Full record

ArticleACS measurement science au2021

Artificial Synapse: Spatiotemporal Heterogeneities in Dopamine Electrochemistry at a Carbon Fiber Ultramicroelectrode.

Baoping Chen, David Perry, James Teahan, Ian J McPherson, James Edmondson, Minkyung Kang, Dimitrios Valavanis, Bruno G Frenguelli, Patrick R Unwin

Abstract read
In one paragraph

Article in ACS measurement science au, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Surface Nanostructure Effects on Dopamine Adsorption and Electrochemistry on Glassy Carbon Electrodes.The journal of physical chemistry. C, Nanomaterials and interfaces · 2022
    Article
  7. Article
  8. Atomistic Simulations of Dopamine Diffusion Dynamics on a Pristine Graphene Surface.Chemphyschem : a European journal of chemical physics and physical chemistry · 2022
    Article
  9. ACS measurement science au · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Baoping ChenDepartment of Chemistry, Molecular Analytical Science Centre for Doctoral Training, and School of Life Sciences, University of Warwick, Coventry, CV4 7AL, United Kingdom.ORCID https://orcid.org/0000-0002-5944-092X
David PerryDepartment of Chemistry, Molecular Analytical Science Centre for Doctoral Training, and School of Life Sciences, University of Warwick, Coventry, CV4 7AL, United Kingdom.ORCID https://orcid.org/0000-0002-8630-4798
James TeahanDepartment of Chemistry, Molecular Analytical Science Centre for Doctoral Training, and School of Life Sciences, University of Warwick, Coventry, CV4 7AL, United Kingdom.
Ian J McPhersonDepartment of Chemistry, Molecular Analytical Science Centre for Doctoral Training, and School of Life Sciences, University of Warwick, Coventry, CV4 7AL, United Kingdom.ORCID https://orcid.org/0000-0002-9377-515X
James EdmondsonDepartment of Chemistry, Molecular Analytical Science Centre for Doctoral Training, and School of Life Sciences, University of Warwick, Coventry, CV4 7AL, United Kingdom.
Minkyung KangDepartment of Chemistry, Molecular Analytical Science Centre for Doctoral Training, and School of Life Sciences, University of Warwick, Coventry, CV4 7AL, United Kingdom.ORCID https://orcid.org/0000-0003-3248-8496
Dimitrios ValavanisDepartment of Chemistry, Molecular Analytical Science Centre for Doctoral Training, and School of Life Sciences, University of Warwick, Coventry, CV4 7AL, United Kingdom.ORCID https://orcid.org/0000-0002-8777-664X
Bruno G FrenguelliDepartment of Chemistry, Molecular Analytical Science Centre for Doctoral Training, and School of Life Sciences, University of Warwick, Coventry, CV4 7AL, United Kingdom.
Patrick R UnwinDepartment of Chemistry, Molecular Analytical Science Centre for Doctoral Training, and School of Life Sciences, University of Warwick, Coventry, CV4 7AL, United Kingdom.ORCID https://orcid.org/0000-0003-3106-2178

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An artificial synapse is developed that mimics ultramicroelectrode (UME) amperometric detection of single cell exocytosis. It comprises the nanopipette of a scanning ion conductance microscope (SICM), which delivers rapid pulses of neurotransmitter (dopamine) locally and on demand at >1000 defined locations of a carbon fiber (CF) UME in each experiment. Analysis of the resulting UME current-space-time data reveals spatiotemporal heterogeneous electrode activity on the nanoscale and submillisecond time scale for dopamine electrooxidation at typical UME detection potentials. Through complementary surface charge mapping and finite element method (FEM) simulations, these previously unseen variations in electrochemical activity are related to heterogeneities in the surface chemistry of the CF UME.

Identifiers

PMID36785735
PMCPMC9836071

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.