Evidence map›Paper›PMID 36785724›Full record

ArticleACS measurement science au2022

Simultaneous Measurement of Striatal Dopamine and Hydrogen Peroxide Transients Associated with L-DOPA Induced Rotation in Hemiparkinsonian Rats.

Leslie R Wilson, Christie A Lee, Catherine F Mason, Sitora Khodjaniyazova, Kevin B Flores, David C Muddiman, Leslie A Sombers

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS measurement science au, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Leslie R WilsonDepartment of Chemistry, Department of Mathematics, Molecular Education, Technology, and Research Innovation Center (METRIC), Center for Research in Scientific Computation, and Comparative Medicine Institute, North Carolina State University, Raleigh, North Carolina 27695, United States.
Christie A LeeDepartment of Chemistry, Department of Mathematics, Molecular Education, Technology, and Research Innovation Center (METRIC), Center for Research in Scientific Computation, and Comparative Medicine Institute, North Carolina State University, Raleigh, North Carolina 27695, United States.
Catherine F MasonDepartment of Chemistry, Department of Mathematics, Molecular Education, Technology, and Research Innovation Center (METRIC), Center for Research in Scientific Computation, and Comparative Medicine Institute, North Carolina State University, Raleigh, North Carolina 27695, United States.
Sitora KhodjaniyazovaDepartment of Chemistry, Department of Mathematics, Molecular Education, Technology, and Research Innovation Center (METRIC), Center for Research in Scientific Computation, and Comparative Medicine Institute, North Carolina State University, Raleigh, North Carolina 27695, United States.
Kevin B FloresDepartment of Chemistry, Department of Mathematics, Molecular Education, Technology, and Research Innovation Center (METRIC), Center for Research in Scientific Computation, and Comparative Medicine Institute, North Carolina State University, Raleigh, North Carolina 27695, United States.
David C MuddimanDepartment of Chemistry, Department of Mathematics, Molecular Education, Technology, and Research Innovation Center (METRIC), Center for Research in Scientific Computation, and Comparative Medicine Institute, North Carolina State University, Raleigh, North Carolina 27695, United States.ORCID https://orcid.org/0000-0003-2216-499X
Leslie A SombersDepartment of Chemistry, Department of Mathematics, Molecular Education, Technology, and Research Innovation Center (METRIC), Center for Research in Scientific Computation, and Comparative Medicine Institute, North Carolina State University, Raleigh, North Carolina 27695, United States.ORCID https://orcid.org/0000-0002-0978-9795
North Carolina State University · US

Funding

Development and Application of New Ionization Methods for Biological Mass SpectrometryR01GM087964 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI MUDDIMAN, DAVID C. · 2010 to 2025
$4.7M
Quantitation of Simultaneous Hydrogen Peroxide and Dopamine Dynamics In VivoR01NS076772 · NINDS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI SOMBERS, LESLIE A · 2011 to 2016
$1.5M
The effect of aging and cognitive impairment on prefrontal cortical inputs to motor cortical outputs during standing balance controlF31AG081129 · NIA · EMORY UNIVERSITY · PI Catherine Francoise Mason · 2023 to 2026
$196k
NIA NIH HHS F31 AG081129NIGMS NIH HHS R01 GM087964NINDS NIH HHS R01 NS076772
6 · The paper itself

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder commonly treated with levodopa (L-DOPA), which eventually induces abnormal involuntary movements (AIMs). The neurochemical contributors to these dyskinesias are unknown; however, several lines of evidence indicate an interplay of dopamine (DA) and oxidative stress. Here, DA and hydrogen peroxide (H

Identifiers

PMID36785724
PMCPMC9838821
OpenAlexW3213030068

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.