Evidence map›Paper›PMID 36785703›Full record

ReviewMaterials today. Advances2022

Calcium carbonate vaterite particles for drug delivery: Advances and challenges.

Daria B Trushina, Tatiana N Borodina, Sergei Belyakov, Maria N Antipina

Abstract readReview
In one paragraph

Review in Materials today. Advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. EngineeringACS synthetic biology · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Systematic Study of Preparing Porous CaCONanomaterials (Basel, Switzerland) · 2025
    Article
  12. New Anticancer Agents: Design, Synthesis and Evaluation.International journal of molecular sciences · 2025
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. [Application of drug delivery microspheres in cancer therapy].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2024
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Daria B TrushinaA.V. Shubnikov Institute of Crystallography of Federal Research Centre "Crystallography and Photonics" of Russian Academy of Sciences, Russian Academy of Sciences, Moscow, 119333, Russia.
Tatiana N BorodinaA.V. Shubnikov Institute of Crystallography of Federal Research Centre "Crystallography and Photonics" of Russian Academy of Sciences, Russian Academy of Sciences, Moscow, 119333, Russia.
Sergei BelyakovTheracross Technologies Pte Ltd, 251 Pasir Panjang Rd, Singapore, 118610, Singapore.
Maria N AntipinaSingapore Institute of Food and Biotechnology Innovation A∗STAR, 31 Biopolis Way, #01-02 Nanos, Singapore, 138669, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The recent successful application of lipid-based nanoparticles as delivery vehicles in COVID-19 vaccines demonstrated the superior potential of nanoparticle-based technology for targeted drug delivery in biomedicine. Among novel, rapidly advancing delivery platforms, the inorganic nano/microparticles gradually reach new heights and attract well-deserved attention among scientists and clinicians. Calcium carbonate in its vaterite form is used as a biocompatible carrier for a progressively increasing number of biomedical applications. Its growing popularity is conferred by beneficial porosity of particles, high mechanical stability, biodegradability under certain physiological conditions, ability to provide a continuous steady release of bioactives, preferential safety profile, and low cost, which make calcium carbonate a suitable entity of highly efficacious formulations for controlled drug delivery and release. The focal point of the current review is the success of the recent vaterite applications in the delivery of various diagnostics and therapeutic drugs. The manuscript highlights the nuances of drug loading in vaterite particles, connecting it with particle morphology, size, and charge of the loaded molecules, payload concentration, mono- or multiple drug loading. The manuscript also depicts recent successful methods of increasing the loading capacity developed for vaterite carriers. In addition, the review describes the various administration routes for vaterite particles with bioactive payloads, which were reported in recent years. Special attention is given to the multi-drug-loaded vaterite particles ("molecular cocktails") and reports on their successful delivery

Indexed as

Drug deliveryLoading capacityLoading methodsMulti-drug loadingTumor-targetingVaterite

Identifiers

PMID36785703
PMCPMC9909585

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.