Evidence map›Paper›PMID 36785701›Full record

ArticleJournal of intensive medicine2022

Clinical significance of serum IgM and IgG levels in COVID-19 patients in Hubei Province, China.

Zhenjiang Bai, Qing Li, Qinghui Chen, Changming Niu, Yu Wei, Hanpeng Huang, Wei Zhao, Nian Chen, Xin Yao, Qiang Zhang and 14 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of intensive medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 8 institutions in 1 country.

Zhenjiang BaiPediatric Intensive Care Unit, Children's Hospital of Soochow University, Suzhou, Jiangsu 215025, China.
Qing LiDepartment of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, China.
Qinghui ChenDepartment of Infectious Diseases, Children's Hospital of Soochow University, Suzhou, Jiangsu 215025, China.
Changming NiuDepartment of Critical Care Medicine, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210011, China.
Yu WeiDepartment of Respirology, Jiangsu Province Hospital of TCM, Nanjing, Jiangsu 210046, China.
Hanpeng HuangDepartment of Respirology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, China.
Wei ZhaoDepartment of Critical Care Medicine, Sir Run Hospital Nanjing Medical University, Nanjing, Jiangsu 211112, China.
Nian ChenDepartment of Infectious Diseases, The Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 211103, China.
Xin YaoDepartment of Respiratory and Critical Care Medicine, The Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 211103, China.
Qiang ZhangDepartment of Respirology, Southeast University Zhongda Hospital, Nanjing, Jiangsu 210009, China.
Chuanyong MuDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China.
Jian FengDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226019, China.
Chuanlong ZhuDepartment of Infectious Diseases, The Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 211103, China.
Zhuo LiDepartment of Emergency, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, China.
Ming DingDepartment of Respirology, Southeast University Zhongda Hospital, Nanjing, Jiangsu 210009, China.
Binhui FengDepartment of Critical Care Medicine, Huangshi Central Hospital, Huangshi, Hubei 435002, China.
Chaochao JinDepartment of Oncology, Huangshi Hospital of TCM (Infectious Disease Hospital, Huangshi, Hubei 435002, China.
Xiang LuDepartment of Geriatric Medicine, Sir Run Hospital Nanjing Medical University, Nanjing, Jiangsu 211112, China.
Yi YangDepartment of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, China.
Shuiyan WuPediatric Intensive Care Unit, Children's Hospital of Soochow University, Suzhou, Jiangsu 215025, China.
Xiaochen ShuDepartment of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu 215031, China.
Lifang HuJiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu 215031, China.
Haibo QiuDepartment of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, China.
YingZi HuangDepartment of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, China.
Soochow University · CNNanjing Medical University · CNZhongda Hospital Southeast University · CNAffiliated Hospital of Jiangsu University · CNHuangshi Central Hospital · CNSecond Affiliated Hospital of Nanjing Medical University · CNAffiliated Hospital of Nantong University · CNJiangsu Province Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: There have been many studies about coronavirus disease 2019 (COVID-19), but the clinical significance of quantitative serum severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)-specific IgM and IgG levels of COVID-19 patients have not been exhaustively analyzed. We aimed to investigate the time profiles of these IgM/IgG levels in COVID-19 patients and their correlations with clinical features. Methods: A multicenter clinical study was conducted from February 20 to March 5 2020. It involved 179 COVID-19 patients (108 males and 71 females) from five hospitals in Huangshi in Hubei Province, China. To detect SARS-CoV-2-specific IgM/IgG, quantitative antibody assays (two-step indirect immunoassays with direct chemiluminescence technology) based on the nucleocapsid protein (NP) and spike protein 1 (S1) were used. For normally distributed data, means were compared using the Results: The median age was 57 (44-69) years (58 [38-69] for males and 57 [49-68] for females). The median duration of positive nucleic acid test was 22.32 (17.34-27.43) days. The mortality rate was relatively low (3/179, 1.68%). Serum SARS-CoV-2-specific IgG was detected around week 1 after illness onset, gradually increased until peaking in weeks 4 and 5, and then declined. Serum IgM peaked in weeks 2 and 3, then gradually declined and returned to its normal range by week 7 in all patients. Notably, children had milder respiratory symptoms with lower SARS-CoV-2-specific IgM/IgG levels. The duration of positive nucleic acid test in the chronic obstructive pulmonary disease (COPD) group was 30.36 (18.99-34.76) days, which was significantly longer than that in the non-COPD group (21.52 [16.75-26.51] days; Conclusions: Quantitative SARS-CoV-2-specific IgM and IgG levels are helpful for the diagnosis, severity classification, and management of COVID-19 patients, and they should be monitored in each stage of this disease.

Indexed as

Clinical significanceCOVID-19Serum IgGSerum IgMSevere acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)

Identifiers

PMID36785701
PMCPMC8487787
OpenAlexW3205675062

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.