ArticleMetabolism open2023
The effect of progressive endurance training and extract of black winter truffle on proteins levels and expression of hippocampus α-synuclein and HSF1 in the healthy and diabetic rats.
Article in Metabolism open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 1 citations in OpenAlex.
- Bioactive Compounds and Antioxidant Potential of Truffles: A Comprehensive Review.Antioxidants (Basel, Switzerland) · 2025Review
- Endurance training promotes the browning of WAT by enhancing the NPFF pathway in the hypothalamus in rats with type 2 diabetes.Iranian journal of basic medical sciences · 2025Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim: The research aimed to investigate the effect of endurance running and Methods: A total of 40 Wistar rats were randomly divided into eight groups: Control (C), Exercise (E), Control-Tuber (T), Exercise-Tuber (ET), Control-Diabetes (D), Exercise-Diabetes (ED), Control-Diabetes-Tuber (CDT), and Exercise-Diabetes-Tuber (EDT). The endurance running was carried out five times per week for five weeks. The hippocampus and the serum α-Syn and HSF1 were measured using an enzyme-linked immunosorbent assay method. Results: The brain α-Syn levels were higher in diabetic groups than in the healthy groups, but insignificantly (P ≤ 0.05). The brain α-Syn level significantly increased in the EDT group compared to the T group (P ≤ 0.05). The serum level of α-Syn in the ED group was significantly higher than in the E and D groups (P ≤ 0.05). The brain HSF1 level was significantly higher in the ED group compared to the D group (P ≤ 0.05). The gene expression of Conclusion: The results of this study suggest that progressive endurance running may improve neuroprotective conditions in diabetic patients by increasing HSF1 in the brain.
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