Evidence map›Paper›PMID 36785512›Full record

ArticleBiophysical journal2023

Chemical potential measurements constrain models of cholesterol-phosphatidylcholine interactions.

Thomas R Shaw, Kathleen C Wisser, Taylor A Schaffner, Anna D Gaffney, Benjamin B Machta, Sarah L Veatch

Open access · greenAbstract read
In one paragraph

Article in Biophysical journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

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  9. Experimentally determined leaflet-leaflet phase diagram of an asymmetric lipid bilayer.Proceedings of the National Academy of Sciences of the United States of America · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Thomas R ShawProgram in Biophysics, University of Michigan, Ann Arbor, Michigan; Program in Applied Physics, University of Michigan, Ann Arbor, Michigan.
Kathleen C WisserProgram in Biophysics, University of Michigan, Ann Arbor, Michigan.
Taylor A SchaffnerDepartment of Physics, Yale University, New Haven, Connecticut.
Anna D GaffneyProgram in Biophysics, University of Michigan, Ann Arbor, Michigan.
Benjamin B MachtaDepartment of Physics, Yale University, New Haven, Connecticut.
Sarah L VeatchProgram in Biophysics, University of Michigan, Ann Arbor, Michigan; Program in Applied Physics, University of Michigan, Ann Arbor, Michigan. Electronic address: sveatch@umich.edu.
University of Michigan · USYale University · US

Funding

The functional organization of mammalian membranes-Equipment SupplementR35GM134949 · NIGMS · UNIVERSITY OF VIRGINIA · PI Ilya Levental · 2020 to 2026
$3.8M
Ion channel regulation by heterogeneous membranesR01GM110052 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI VEATCH, SARAH L · 2014 to 2022
$2.9M
Physics and Systems Biology of Cellular DomainsR35GM138341 · NIGMS · YALE UNIVERSITY · PI MACHTA, BENJAMIN BROOKS · 2020 to 2024
$2.0M
Ion channel regulation by heterogeneous membranesR01GM129347 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI VEATCH, SARAH L · 2019 to 2022
$1.1M
NIGMS NIH HHS R01 GM110052NIGMS NIH HHS R01 GM129347NIGMS NIH HHS R35 GM134949NIGMS NIH HHS R35 GM138341
6 · The paper itself

Abstract

Bilayer membranes composed of cholesterol and phospholipids exhibit diverse forms of nonideal mixing. In particular, many previous studies document macroscopic liquid-liquid phase separation as well as nanometer-scale heterogeneity in membranes of phosphatidylcholine (PC) lipids and cholesterol. Here, we present experimental measurements of cholesterol chemical potential (μ

Indexed as

CholesterolPhosphatidylcholinesLipid BilayersThermodynamicsCholesterolLipid BilayersPhosphatidylcholines

Identifiers

PMID36785512
PMCPMC10111267
OpenAlexW4320498008

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.